Journal article
Kawasaki Disease and Exposure to Fine Particulate Air Pollution
The Journal of pediatrics, v 177, pp 179-183
01 Oct 2016
PMID: 27496266
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To analyze associations of short-term exposure to fine particulate matter (diameter ≤ 2.5 µm [PM2.5]), a measurable component of urban pollution, with the event date of fever onset for patients with Kawasaki disease (KD) residing in 7 metropolitan regions.
A case-crossover study design was used. Time trends, seasonality, month, and weekday were controlled for by matching. We assembled PM2.5 exposure measurements from urban monitors and imputed PM2.5 to provide day-to-day temporal variability and resolution for time series indexes of exposures. Selected exposure windows (to 14 days) of PM2.5 were examined.
A total of 3009 KD events were included for which the subject resided within a study metropolitan area and the event date occurred during years with available PM2.5. The estimated ORs (with 95% CIs) of an event of KD associated with a 10 µg/m3 PM2.5 lagged moving average concentration of lagged exposure period (ie, concurrent, preceding day[s]) revealed no evidence of a consistent, statistically significant, positive association between elevated PM2.5 exposure and increased risk of KD. Extended analysis with stratification by city, sex, age, ethnic origin, incomplete or complete clinical manifestations, the presence of coronary aneurysm, and intravenous immunoglobulin resistance did not provide evidence of a consistent, statistically significant, positive association between elevated exposure to PM2.5 and increased risk of KD for any of the strata studied.
This multicity study failed to establish a risk of the event of KD with short-term fine particulate exposure. Our negative findings add to the growing field of environmental epidemiology research of KD.
Metrics
Details
- Title
- Kawasaki Disease and Exposure to Fine Particulate Air Pollution
- Creators
- Andrew S. Zeft - Cleveland ClinicJane C. Burns - University of California, San DiegoRae S. Yeung - University of TorontoBrian W. McCrindle - University of TorontoJane W. Newburger - Harvard UniversitySamuel R. Dominguez - University of Colorado DenverMarsha S. Anderson - University of Colorado DenverCammon Arrington - University of UtahStanford T. Shulman - Northwestern UniversityJeein Yoon - Cleveland ClinicHelen Tewelde - Cleveland ClinicCarter Mix - Brigham Young UniversityC. Arden Pope - Brigham Young University
- Publication Details
- The Journal of pediatrics, v 177, pp 179-183
- Publisher
- Elsevier
- Grant note
- STAR R834992 / Environmental Protection Agency (http://dx.doi.org/10.13039/501100001589)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000390022700037
- Scopus ID
- 2-s2.0-84997606262
- Other Identifier
- 991021861874504721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Pediatrics