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Kefir peptides alleviate high-fat diet-induced atherosclerosis by attenuating macrophage accumulation and oxidative stress in ApoE knockout mice
Journal article   Open access   Peer reviewed

Kefir peptides alleviate high-fat diet-induced atherosclerosis by attenuating macrophage accumulation and oxidative stress in ApoE knockout mice

Min-Che Tung, Ying-Wei Lan, Hsin-Han Li, Hsiao-Ling Chen, Sheng-Yi Chen, Yu-Hsuan Chen, Chi-Chien Lin, Min-Yu Tu and Chuan-Mu Chen
Scientific reports, v 10(1), pp 8802-8802
29 May 2020
DOI: https://doi.org/10.1038/s41598-020-65782-8
PMID: 32472055
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://www.nature.com/articles/s41598-020-65782-8.pdfView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1038/s41598-020-65782-8View
Published, Version of Record (VoR) Open

Abstract

Administration, Oral Animals Atherosclerosis - chemically induced Atherosclerosis - drug therapy Atherosclerosis - genetics Atherosclerosis - immunology Diet, High-Fat - adverse effects Humans Kefir Lipid Metabolism - drug effects Macrophages - metabolism Male Mice Mice, Knockout, ApoE Oxidative Stress - drug effects Peptides - administration & dosage Peptides - pharmacology THP-1 Cells
In the past decade, the high morbidity and mortality of atherosclerotic disease have been prevalent worldwide. High-fat food consumption has been suggested to be an overarching factor for atherosclerosis incidence. This study aims to investigate the effects of kefir peptides on high-fat diet (HFD)-induced atherosclerosis in apolipoprotein E knockout (ApoE ) mice. 7-week old male ApoE and normal C57BL/6 mice were randomly divided into five groups (n = 8). Atherosclerotic lesion development in ApoE mice was established after fed the HFD for 12 weeks compared to standard chow diet (SCD)-fed C57BL/6 and ApoE control groups. Kefir peptides oral administration significantly improved atherosclerotic lesion development by protecting against endothelial dysfunction, decreasing oxidative stress, reducing aortic lipid deposition, attenuating macrophage accumulation, and suppressing the inflammatory immune response compared with the HFD/ApoE mock group. Moreover, the high dose of kefir peptides substantially inhibited aortic fibrosis and restored the fibrosis in the aorta root close to that observed in the C57BL/6 normal control group. Our findings show, for the first time, anti-atherosclerotic progression via kefir peptides consumption in HFD-fed ApoE mice. The profitable effects of kefir peptides provide new perspectives for its use as an anti-atherosclerotic agent in the preventive medicine.

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38 citations in Web of Science
37 citations in Scopus

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UN Sustainable Development Goals (SDGs)

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#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Cardiac & Cardiovascular Systems
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