Journal article
Kidney Function and Cognitive Impairment in US Adults: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study
American journal of kidney diseases, v 52(2), pp 227-234
2008
PMID: 18585836
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Abstract
The association between kidney function and cognitive impairment has not been assessed in a national sample with a wide spectrum of kidney disease severity.
Cross-sectional.
23,405 participants (mean age, 64.9 ± 9.6 years) with baseline measurements of creatinine and cognitive function participating in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study, a study of stroke risk factors in a large national sample.
Estimated glomerular filtration rate (eGFR).
Cognitive impairment.
Chronic kidney disease (CKD) was defined as eGFR less than 60 mL/min/1.73 m
2. Kidney function was analyzed in 10-mL/min/1.73 m
2 increments in those with CKD, and in exploratory analyses, across the range of kidney function. Cognitive function was assessed using the 6-Item Screener, and participants with a score of 4 or less were considered to have cognitive impairment.
CKD was associated with an increased prevalence of cognitive impairment independent of confounding factors (odds ratio, 1.23; 95% confidence interval, 1.06 to 1.43). In patients with CKD, each 10-mL/min/1.73 m
2 decrease in eGFR less than 60 mL/min/1.73 m
2 was associated with an 11% increased prevalence of impairment (odds ratio, 1.11; 95% confidence interval, 1.04 to 1.19). Exploratory analyses showed a nonlinear association between eGFR and prevalence of cognitive impairment, with a significant increased prevalence of impairment in those with eGFR less than 50 and 100 mL/min/1.73 m
2 or greater.
Longitudinal measures of cognitive function were not available.
In US adults, lower levels of kidney function are associated with an increased prevalence of cognitive impairment. The prevalence of impairment appears to increase early in the course of kidney disease; therefore, screening for impairment should be considered in all adults with CKD.
Metrics
Details
- Title
- Kidney Function and Cognitive Impairment in US Adults: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study
- Creators
- Manjula Kurella Tamura - Department of Medicine, University of California San Francisco, San Francisco, CAVirginia Wadley - Geriatric Research Education and Clinical CenterKristine Yaffe - University of California, San FranciscoLeslie A. McClure - University of Alabama at BirminghamGeorge Howard - University of Alabama at BirminghamRodney Go - Department of Epidemiology and Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, ALRichard M. Allman - Geriatric Research Education and Clinical CenterDavid G. Warnock - University of Alabama at BirminghamWilliam McClellan - University of Alabama at Birmingham
- Publication Details
- American journal of kidney diseases, v 52(2), pp 227-234
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000257943400007
- Scopus ID
- 2-s2.0-47149085499
- Other Identifier
- 991019231625604721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Urology & Nephrology