Journal article
Kidney Transplant Outcomes for Prior Living Organ Donors
Journal of the American Society of Nephrology, v 26(5), pp 1188-1194
01 May 2015
PMID: 25412818
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The Organ Procurement and Transplantation Network gives priority in kidney allocation to prior live organ donors who require a kidney transplant. In this study, we analyzed the effect of this policy on facilitating access to transplantation for prior donors who were wait-listed for kidney transplantation in the United States. Using 1:1 propensity score-matching methods, we assembled two matched cohorts. The first cohort consisted of prior organ donors and matched nondonors who were wait-listed during the years 1996-2010. The second cohort consisted of prior organ donors and matched nondonors who underwent deceased donor kidney transplantation. During the study period, there were 385,498 listings for kidney transplantation, 252 of which were prior donors. Most prior donors required dialysis by the time of listing (64% versus 69% among matched candidates; P=0.24). Compared with matched nondonors, prior donors had a higher rate of deceased donor transplant (85% versus 33%; P<0.001) and a lower median time to transplantation (145 versus 1607 days; P<0.001). Prior donors received higher-quality allografts (median kidney donor risk index 0.67 versus 0.90 for nondonors; P<0.001) and experienced lower post-transplant mortality (hazard ratio, 0.19; 95% confidence interval, 0.08 to 0.46; P<0.001) than matched nondonors. In conclusion, these data suggest that prior organ donors experience brief waiting time for kidney transplant and receive excellent-quality kidneys, but most need pretransplant dialysis. Individuals who are considering live organ donation should be provided with this information because this allocation priority will remain in place under the new US kidney allocation system.
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Details
- Title
- Kidney Transplant Outcomes for Prior Living Organ Donors
- Creators
- Vishnu Potluri - Lankenau Medical CenterMeera N. Harhay - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaF. Perry Wilson - Yale UniversityRoy D. Bloom - Raymond and Ruth Perelman School of Medicine at the University of PennsylvaniaPeter P. Reese - Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania
- Publication Details
- Journal of the American Society of Nephrology, v 26(5), pp 1188-1194
- Publisher
- Amer Soc Nephrology
- Number of pages
- 7
- Grant note
- F32-DK096758-01; DK097201 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) K23DK097201 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000353868200022
- Scopus ID
- 2-s2.0-84929336808
- Other Identifier
- 991019335614704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Urology & Nephrology