Journal article
Kidney Transplantation in HIV-Positive Patients: A Single-Center, 16-Year Experience
American journal of kidney diseases, v 73(1), pp 112-118
Jan 2019
PMID: 29705074
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hahnemann University Hospital has performed 120 kidney transplantations in human immunodeficiency virus (HIV)-positive individuals during the last 16 years. Our patient population represents ∼10% of the entire US population of HIV-positive kidney recipients. In our earlier years of HIV transplantation, we noted increased rejection rates, often leading to graft failure. We have established a multidisciplinary team and over the years have made substantial protocol modifications based on lessons learned. These modifications affected our approach to candidate evaluation, donor selection, perioperative immunosuppression, and posttransplantation monitoring and resulted in excellent posttransplantation outcomes, including 100% patient and graft survival at 1 year and patient and graft survival at 3 years of 100% and 96%, respectively. We present key clinical data, including a granular patient-level analysis of the associations of antiretroviral therapy regimens with long-term survival, cellular and antibody-mediated rejection rates, and the causes of allograft failures. In summary, we provide details on the evolution of our approach to HIV transplantation during the last 16 years, including strategies that may improve outcomes among HIV-positive kidney transplantation candidates throughout the United States.
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Details
- Title
- Kidney Transplantation in HIV-Positive Patients: A Single-Center, 16-Year Experience
- Creators
- Gregory E. Malat - Drexel UniversitySuzanne M. Boyle - Drexel UniversityRahul M. Jindal - USU‐Walter Reed Department of Surgery Uniformed Services University Bethesda MDStephen Guy - Drexel UniversityGary Xiao - Drexel UniversityMeera N. Harhay - Drexel UniversityDong H. Lee - Drexel UniversityKarthik M. Ranganna - Drexel UniversityMysore S. Anil Kumar - Astellas Pharmaceuticals, Northbrook, ILAlden M. Doyle - Drexel University
- Publication Details
- American journal of kidney diseases, v 73(1), pp 112-118
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); College of Medicine; Surgery
- Web of Science ID
- WOS:000453712100016
- Scopus ID
- 2-s2.0-85046154340
- Other Identifier
- 991019169701904721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Urology & Nephrology