Journal article
Kinesigenic dyskinesia in a case of voltage-gated potassium channel-complex protein antibody encephalitis
Archives of neurology (Chicago), v 68(4), pp 529-532
Apr 2011
PMID: 21149804
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To describe the first case (to our knowledge) of voltage-gated potassium channel-complex protein antibody encephalitis with kinesigenic dyskinesia and cramp-fasciculation syndrome.
Case report.
Hospitalized care.
A 38-year-old man with a history of bronchial asthma, eczema, vitiligo, and immune complex mesangiopathic glomerulonephritis presented with abnormal movements.
Clinical examination, magnetic resonance imaging, single-photon emission computed tomography, electromyography and nerve conduction studies, video-electroencephalographic monitoring, plasmapheresis exchange therapy, and intravenous immunoglobulin administration.
Clinical examination revealed paroxysmal kinesigenic dyskinesia and fasciculations. Magnetic resonance imaging of the brain revealed a left caudate and left putamen increased signal lesion on T2-weighted and fluid-attenuated inversion recovery sequences as well as increased flow in the same region on single-photon emission computed tomographic scans. Electromyography and nerve conduction studies revealed significant afterdischarges, cramp potentials, and continuous motor activity. The video-electroencephalographic monitoring revealed no epileptiform discharges. The patient dramatically improved after 5 plasmapheresis exchange treatments and a course of intravenous immunoglobulin at 2 gm/kg over 5 divided doses.
To our knowledge, this is the first report of paroxysmal kinesigenic dyskinesia with voltage-gated potassium channel-complex protein antibody encephalitis associated with the cramp fasciculation syndrome.
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Details
- Title
- Kinesigenic dyskinesia in a case of voltage-gated potassium channel-complex protein antibody encephalitis
- Creators
- Enrique Aradillas - Drexel UniversityRobert J Schwartzman
- Publication Details
- Archives of neurology (Chicago), v 68(4), pp 529-532
- Publisher
- American Medical Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000289368800020
- Scopus ID
- 2-s2.0-79953843909
- Other Identifier
- 991019167618904721
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- Web of Science research areas
- Clinical Neurology