Journal article
Kinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migration
Molecular biology of the cell, v 22(9), pp 1561-1574
May 2011
PMID: 21411631
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Kinesin-5 (also called Eg5 or kif11) is a homotetrameric motor protein that functions by modulating microtubule (MT)-MT interactions. In the case of mitosis, kinesin-5 slows the rate of separation of the half-spindles. In the case of the axon, kinesin-5 limits the frequency of transport of short MTs, and also limits the rate of axonal growth. Here we show that experimental inhibition of kinesin-5 in cultured migratory neurons results in a faster but more randomly moving neuron with a shorter leading process. As is the case with axons of stationary neurons, short MT transport frequency is notably enhanced in the leading process of the migratory neuron when kinesin-5 is inhibited. Conversely, overexpression of kinesin-5, both in culture and in developing cerebral cortex, causes migration to slow and even cease. Regions of anti-parallel MT organization behind the centrosome were shown to be especially rich in kinesin-5, implicating these regions as potential sites where kinesin-5 forces may be especially relevant. We posit that kinesin-5 acts as a "brake" on MT-MT interactions that modulates the advance of the entire MT apparatus. In so doing, kinesin-5 regulates the rate and directionality of neuronal migration and possibly the cessation of migration when the neuron reaches its destination.
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Details
- Title
- Kinesin-5, a mitotic microtubule-associated motor protein, modulates neuronal migration
- Creators
- Aditi Falnikar - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USAShubha TolePeter W Baas
- Publication Details
- Molecular biology of the cell, v 22(9), pp 1561-1574
- Publisher
- United States
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000290023700014
- Scopus ID
- 2-s2.0-79955490607
- Other Identifier
- 991014878245404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology