Journal article
Kismet positively regulates glutamate receptor localization and synaptic transmission at the Drosophila neuromuscular junction
PloS one, v 9(11), pp e113494-e113494
2014
PMID: 25412171
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The Drosophila neuromuscular junction (NMJ) is a glutamatergic synapse that is structurally and functionally similar to mammalian glutamatergic synapses. These synapses can, as a result of changes in activity, alter the strength of their connections via processes that require chromatin remodeling and changes in gene expression. The chromodomain helicase DNA binding (CHD) protein, Kismet (Kis), is expressed in both motor neuron nuclei and postsynaptic muscle nuclei of the Drosophila larvae. Here, we show that Kis is important for motor neuron synaptic morphology, the localization and clustering of postsynaptic glutamate receptors, larval motor behavior, and synaptic transmission. Our data suggest that Kis is part of the machinery that modulates the development and function of the NMJ. Kis is the homolog to human CHD7, which is mutated in CHARGE syndrome. Thus, our data suggest novel avenues of investigation for synaptic defects associated with CHARGE syndrome.
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Details
- Title
- Kismet positively regulates glutamate receptor localization and synaptic transmission at the Drosophila neuromuscular junction
- Creators
- Rupa Ghosh - Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States of AmericaSrikar Vegesna - Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States of AmericaRamia Safi - Department of Biological Sciences, Southern Illinois University Edwardsville, Edwardsville, Illinois, United States of AmericaHong Bao - Division of Biological Sciences, University of Missouri, Columbia, Missouri, United States of AmericaBing Zhang - Division of Biological Sciences, University of Missouri, Columbia, Missouri, United States of AmericaDaniel R Marenda - Department of Biology, Drexel University, Philadelphia, Pennsylvania, United States of America; Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of AmericaFaith L W Liebl - Department of Biological Sciences, Southern Illinois University Edwardsville, Edwardsville, Illinois, United States of America
- Publication Details
- PloS one, v 9(11), pp e113494-e113494
- Publisher
- Public LIbrary of Science (PLOS); United States
- Grant note
- 1R15NS063315-01 / NINDS NIH HHS R01NS060878 / NINDS NIH HHS R01 NS060878 / NINDS NIH HHS R15 NS063315 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000345253000059
- Scopus ID
- 2-s2.0-84912013824
- Other Identifier
- 991014877697604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences