Journal article
Knockdown of KIF26B inhibits breast cancer cell proliferation, migration, and invasion
OncoTargets and therapy, v 11, pp 3195-3203
01 Jan 2018
PMID: 29881293
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: Kinesin family member 26B (KIF26B) plays a key role in the development and progression of many human cancers. However, the role and underlying mechanisms of KIF26B in breast cancer cells remain unknown.
Materials and methods: In this study, we inhibited the expression of KIF26B in MDA-MB-231 and MCF-7 cells using lentivirus-delivered shRNA.
Results: Lentivirus-mediated KIF26B knockdown significantly suppressed cell proliferation, colony formation, migration, and invasion. Furthermore, cell cycle analyses revealed that the percentage of cells in the G0/G1 phase was significantly increased in KIF26B knockdown cells. Moreover, the knockdown of KIF26B significantly promoted cell apoptosis via the upregulation of cleaved caspase-3 and Bax.
Conclusion: Our data indicate that KIF26B plays a pivotal role in tumor growth and metastasis in breast cancer cells and may be a potential therapeutic target for treating breast cancer.
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Details
- Title
- Knockdown of KIF26B inhibits breast cancer cell proliferation, migration, and invasion
- Creators
- Shudong Gu - Affiliated Hospital of Nantong UniversityHaibin Liang - XinHua HospitalDonghui Qi - Nantong UniversityLiyan Mao - XinHua HospitalGuoxin Mao - Affiliated Hospital of Nantong UniversityLi Qian - Affiliated Hospital of Nantong UniversityShu Zhang - Affiliated Hospital of Nantong UniversityHualou Liang - School of Biomedical Engineering, Science, and Health Systems (1997-)
- Publication Details
- OncoTargets and therapy, v 11, pp 3195-3203
- Publisher
- Dove Medical Press Ltd
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000433321700001
- Scopus ID
- 2-s2.0-85047927062
- Other Identifier
- 991019320712904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Oncology