Journal article
Kynurenic Acid and Neuroprotective Activity of the Ketogenic Diet in the Eye
Current medicinal chemistry, v 24(32), pp 3547-3558
01 Jan 2017
PMID: 28486923
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: There is growing evidence of the involvement of the kynurenine metabolic pathway and the enhancement of kynurenic acid production in the neuroprotective effects of the ketogenic diet.
Objective: Here, we review evidence implicating kynurenic acid in the efficacy of ketogenic diet in eye diseases associated with neurodegeneration.
Findings: Ketogenic diet and ketone bodies that are elevated during exposure to the ketogenic diet each have a neuroprotective effect on retinal ganglion cells in a rat model of N-methyl-D-aspartate induced neuronal damage. Chronic exposure to ketogenic diet also increases kynurenic acid concentrations in discrete rat brain structures. A non-selective glutamate receptor agonist, glutamate, also decreases the production of kynurenic acid in bovine retinal slices; this effect is attenuated by acetoacetate and beta-hydroxybutyrate, two of three ketone bodies overproduced during ketogenic diet.
Perspective: Whether ketogenic diet induced enhancement of kynurenic acid production would translate into a clinically significant improvement in certain eye diseases like glaucoma and retinal neurodegenerations awaits further experimental and clinical verification.
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Details
- Title
- Kynurenic Acid and Neuroprotective Activity of the Ketogenic Diet in the Eye
- Creators
- Tomasz Zarnowski - Medical University of LublinMaria Tulidowicz-Bielak - Medical University of LublinIwona Zarnowska - Medical University of LublinKrystyna Mitosek-Szewczyk - Medical University of LublinArtur Wnorowski - Medical University of LublinKrzysztof Jozwiak - Medical University of LublinMaciej Gasior - Drexel UniversityWaldemar A. Turski - Medical University of Lublin
- Publication Details
- Current medicinal chemistry, v 24(32), pp 3547-3558
- Publisher
- Bentham Science Publ Ltd
- Number of pages
- 12
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000414048400005
- Scopus ID
- 2-s2.0-85038253122
- Other Identifier
- 991019168772204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Medicinal
- Pharmacology & Pharmacy