Journal article
LAN-1 human neuroblastoma cells are provided of endothelin-1 receptors linked to [Ca++]i elevation
Functional neurology, v 7(3), pp 239-242
May 1992
PMID: 1323509
Abstract
Endothelin-1 (ET-1) produced a dose-dependent increase of intracellular Ca++ concentrations [Ca++]i characterized by an early peak phase and a delayed plateau in LAN-1 human neuroblastoma cells. The ET-1 receptor showed a rapid desensitization since a second pulse application of ET-1 did not elicit a further [Ca++]i increase. Furthermore thapsigargin, an endoplasmic reticulum Ca(++)-ATPase inhibitor, completely abolished the ET-1 induced intracellular Ca++ elevation.
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Details
- Title
- LAN-1 human neuroblastoma cells are provided of endothelin-1 receptors linked to [Ca++]i elevation
- Creators
- A Fatatis - Department of Human Communication Sciences, 2nd School of Medicine, Federico II University of Naples, ItalyA BassiG MitaG F Di RenzoL Annunziato
- Publication Details
- Functional neurology, v 7(3), pp 239-242
- Publisher
- Italy
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Scopus ID
- 2-s2.0-0026763973
- Other Identifier
- 991014878343504721