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Lab-on-a-chip for oral cancer screening and diagnosis
Journal article   Open access   Peer reviewed

Lab-on-a-chip for oral cancer screening and diagnosis

Barry L Ziober, Michael G Mauk, Erica M Falls, Zongyuan Chen, Amy F Ziober and Haim H Bau
Head & neck, v 30(1), pp 111-121
Jan 2008
DOI: https://doi.org/10.1002/hed.20680
PMID: 17902150
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://repository.upenn.edu/cgi/viewcontent.cgi?article=1143&context=meam_papersView
SubmittedOpen Access (License Unspecified),  Open
url
https://doi.org/10.1002/hed.20680View
Published, Version of Record (VoR) Open

Abstract

Microfluidic Analytical Techniques Mass Screening - instrumentation Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Humans Mouth Neoplasms - metabolism Gene Expression Profiling RNA, Messenger - metabolism Reverse Transcriptase Polymerase Chain Reaction Biomarkers, Tumor Cell Adhesion Molecules - metabolism Mass Screening - methods Epithelial Cell Adhesion Molecule Carcinoma, Squamous Cell - diagnosis Mouth Neoplasms - diagnosis Carrier Proteins - metabolism Antigens, Neoplasm - metabolism Transcription, Genetic Software Mouth Neoplasms - genetics
Oral squamous cell carcinoma (OSCC) is a disfiguring and deadly cancer. Despite advances in therapy, many patients continue to face a poor prognosis. Early detection is an important factor in determining the survival of patients with OSCC. No accurate, cost-efficient, and reproducible method exists to screen patients for OSCC. As a result, many patients are diagnosed at advanced stages of the disease. Early detection would identify patients, facilitating timely treatment and close monitoring. Mass screening requires a rapid oral cancer diagnostic test that can be used in a clinical setting. Current diagnostic techniques for OSCC require modern laboratory facilities, sophisticated equipment, and elaborate and lengthy processing by skilled personnel. The lab-on-chip technology holds the promise of replacing these techniques with miniaturized, integrated, automated, inexpensive diagnostic devices. This article describes lab-on-chip devices for biomarker-based identification of oral cancer. Similar methods can be employed for the screening of other types of cancers.

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62 citations in Web of Science
81 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Web of Science research areas
Otorhinolaryngology
Surgery
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