Journal article
Lab-on-a-chip technologies for oral-based cancer screening and diagnostics: capabilities, issues, and prospects
Annals of the New York Academy of Sciences, v 1098(1), pp 467-475
Mar 2007
PMID: 17435153
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The design of a microfluidic lab-on-a-chip system for point-of-care cancer screening and diagnosis of oral squamous cell carcinoma (OSCC) is presented. The chip is based on determining a approximately 30-gene transcription profile in cancer cells isolated from oral fluid samples. Microfluidic cell sorting using magnetic beads functionalized with an antibody against cancer-specific cell-surface antigens (e.g., epithelial cell adhesion molecule [EpCAM]) is described. A comprehensive cancer diagnostics chip will integrate microfluidic components for cell lysis, nucleic acid extraction, and amplification and detection of a panel of mRNA isolated from a subpopulation of cancer cells contained in a clinical specimen.
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Details
- Title
- Lab-on-a-chip technologies for oral-based cancer screening and diagnostics: capabilities, issues, and prospects
- Creators
- Michael G Mauk - Department of Mechanical Engineering and Applied Science, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6315, USABarry L ZioberZongyuan ChenJason A ThompsonHaim H Bau
- Publication Details
- Annals of the New York Academy of Sciences, v 1098(1), pp 467-475
- Publisher
- United States
- Grant note
- UO1DE0114964 / NIDCR NIH HHS UO1DE017855 / NIDCR NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Engineering Technology
- Web of Science ID
- WOS:000246091500036
- Scopus ID
- 2-s2.0-34248215135
- Other Identifier
- 991014877936504721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Dentistry, Oral Surgery & Medicine
- Medical Laboratory Technology