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Laboratory Evaluation of Spasmodic Dysphonia
Journal article   Peer reviewed

Laboratory Evaluation of Spasmodic Dysphonia

Sammy Othman, Srihari Daggumati, Rohan Patel, Justin Ross and Robert T. Sataloff
Journal of voice, v 34(6), pp 934-939
Nov 2020
DOI: https://doi.org/10.1016/j.jvoice.2019.05.016
PMID: 31288958
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Dystonia Laboratory Spasmodic dysphonia Vocal fold dystonia Vocal fold spasms Work-up
To evaluate the utility of comprehensive laboratory evaluation in patients with spasmodic dysphonia (SD). Retrospective chart review. A review of the medical records of 40 patients diagnosed with spasmodic dysphonia from 2009-2018 was preformed to evaluate abnormal test results that were significant when compared with abnormal results of the general population and for any other clinically relevant pathology. Erythrocyte sedimentation rate, ceruloplasmin levels, and anti-AChR were found to be elevated at levels considered statistically significant (p <0.05). Furthermore, we found levels of cholesterol, thyroid-stimulating hormone (TSH), T3, fasting blood glucose, creatine kinase, immunoglobulin, antinuclear antibody (ANA), and alpha-fetoprotein (AFP) levels to be abnormal at a greater rate in our population, but these were not statistically significant. Workup revealed several underlying conditions including thyroid neoplasms, hypothyroidism, and laryngopharyngeal reflux. Additionally, brain MRI revealed age-related ischemic pathology in an elevated number of patients, but with no obvious clinical sequalae. There is an association between serological values and spasmodic dysphonia that can aid in diagnosing pathology, as well as establishing a directed workup. Additionally, our study shows the utility of comprehensive evaluation in identifying undetected disease.

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5 citations in Web of Science
5 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Audiology & Speech-language Pathology
Otorhinolaryngology
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