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Laboratory Evaluation of Vocal Fold Paralysis and Paresis
Journal article

Laboratory Evaluation of Vocal Fold Paralysis and Paresis

Michelle White, Kirsten Meenan, Tirth Patel, Aaron Jaworek and Robert T Sataloff
Journal of voice, v 31(2)
Mar 2017
DOI: https://doi.org/10.1016/j.jvoice.2016.07.022
PMID: 27777055
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Adult Aged Biomarkers - blood Dysphonia - diagnosis Dysphonia - physiopathology Female Humans Incidence Leukocyte Count Lyme Disease - diagnosis Lyme Disease - epidemiology Male Middle Aged Myasthenia Gravis - epidemiology Philadelphia - epidemiology Predictive Value of Tests Prevalence Reproducibility of Results Retrospective Studies Risk Factors Serologic Tests Severity of Illness Index Syphilis - diagnosis Syphilis - epidemiology Vocal Cord Paralysis - blood Vocal Cord Paralysis - diagnosis Vocal Cord Paralysis - epidemiology Vocal Cord Paralysis - physiopathology Vocal Cords - physiopathology Voice Quality
This study aimed to assess the value of comprehensive laboratory evaluation in patients with vocal fold paralysis or paresis. This is a retrospective chart review. Records of 231 patients with vocal fold paralysis or paresis were reviewed to determine whether there is a significant increase in the number of abnormal test results compared with rates of abnormal results for these tests in the general population and whether testing resulted in clinically important diagnosis. Laboratory data were collected from charts from initial visits from 2010 to 2014 and compared with national data. When controlled for age and sex, white blood cell count was found to have a significantly higher rate of abnormal test results (P < 0.001) in patients with vocal fold paralysis or paresis than the general population. Although hemoglobin, thyroid-stimulating hormone, and thyroid antibody tests were more likely to be abnormal in our patient population, the trend was not statistically significant. Further, the prevalence of syphilis and myasthenia gravis was found to be higher in these subjects than their respective national prevalences, and the incidence of Lyme disease was found to be higher than the national prevalence of Lyme disease. Several patients were diagnosed with medically important conditions such as diabetes, thyroid dysfunction, syphilis, myasthenia gravis, and Lyme disease based on these tests. This study suggests that comprehensive testing of patients with vocal fold movement disorders results in diagnoses that would be missed without a comprehensive evaluation, some of which are important medically, although their causal relationship to vocal fold paralysis or paresis was not investigated or established.

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10 Record Views
9 citations in Web of Science
15 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Audiology & Speech-language Pathology
Otorhinolaryngology
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