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Journal article
Lack of significant association between type 2 diabetes mellitus with longitudinal change in diurnal salivary cortisol: the multiethnic study of atherosclerosis
Endocrine, v 53(1)
Jul 2016
PMID: 26895003
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cross-sectional association has been shown between type 2 diabetes and hypothalamic-pituitary-adrenal (HPA) axis dysregulation; however, the temporality of this association is unknown. Our aim was to determine if type 2 diabetes is associated with longitudinal change in daily cortisol curve features. We hypothesized that the presence of type 2 diabetes may lead to a more blunted and abnormal HPA axis profile over time, suggestive of increased HPA axis dysregulation. This was a longitudinal cohort study, including 580 community-dwelling individuals (mean age 63.7 ± 9.1 years; 52.8 % women) with (n = 90) and without (n = 490) type 2 diabetes who attended two MultiEthnic Study of Atherosclerosis Stress ancillary study exams separated by 6 years. Outcome measures that were collected were wake-up and bedtime cortisol, cortisol awakening response (CAR), total area under the curve (AUC), and early, late, and overall decline slopes. In univariate analyses, wake-up and AUC increased over 6 years more in persons with as compared to those without type 2 diabetes (11 vs. 7 % increase for wake-up and 17 vs. 11 % for AUC). The early decline slope became flatter over time with a greater flattening observed in diabetic compared to non-diabetic individuals (23 vs. 9 % flatter); however, the change was only statistically significant for wake-up cortisol (p-value: 0.03). Over time, while CAR was reduced more, late decline and overall decline became flatter, and bedtime cortisol increased less in those with as compared to those without type 2 diabetes, none of these changes were statistically significant in adjusted models. We did not identify any statistically significant change in cortisol curve features over 6 years by type 2 diabetes status.
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Details
- Title
- Lack of significant association between type 2 diabetes mellitus with longitudinal change in diurnal salivary cortisol: the multiethnic study of atherosclerosis
- Creators
- Elias K Spanakis - Johns Hopkins UniversityXu Wang - Drexel UniversityBrisa N Sánchez - University of MichiganAna V Diez Roux - Drexel UniversityBelinda L Needham - University of Michigan–Ann ArborGary S Wand - Johns Hopkins MedicineTeresa Seeman - University of California at Los AngelesSherita Hill Golden - Bloomberg
- Publication Details
- Endocrine, v 53(1)
- Publisher
- Springer Nature
- Grant note
- N01HC95159 / NHLBI NIH HHS N01HC95169 / NHLBI NIH HHS F32 HL010161 / NHLBI NIH HHS T32 DK062707 / NIDDK NIH HHS R01 HL101161 / NHLBI NIH HHS R21 DA024273 / NIDA NIH HHS N01HC95165 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative; Epidemiology and Biostatistics
- Web of Science ID
- WOS:000377934000026
- Scopus ID
- 2-s2.0-84958742814
- Other Identifier
- 991019168370804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism