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Lamellar Bone is an Incremental Tissue Reconciling Enamel Rhythms, Body Size, and Organismal Life History
Journal article   Open access   Peer reviewed

Lamellar Bone is an Incremental Tissue Reconciling Enamel Rhythms, Body Size, and Organismal Life History

Timothy Bromage, Rodrigo Lacruz, Russell Hogg, Haviva Goldman, Shannon McFarlin, Johanna Warshaw, Wendy Dirks, Alejandro Perez-Ochoa, Igor Smolyar, Donald Enlow, …
Calcified tissue international, v 84(5), pp 388-404
May 2009
PMID: 19234658
url
https://doi.org/10.1007/s00223-009-9221-2View
Published, Version of Record (VoR) Open

Abstract

Life Sciences Biochemistry, general Life history Chronobiology Orthopedics Bone lamella Endocrinology Enamel striae of Retzius Cell Biology
Mammalian enamel formation is periodic, including fluctuations attributable to the daily biological clock as well as longer-period oscillations that enigmatically correlate with body mass. Because the scaling of bone mass to body mass is an axiom of vertebrate hard tissue biology, we consider that long-period enamel formation rhythms may reflect corresponding and heretofore unrecognized rhythms in bone growth. The principal aim of this study is to seek a rhythm in bone growth demonstrably related to enamel oscillatory development. Our analytical approach is based in morphology, using a variety of hard tissue microscopy techniques. We first ascertain the relationship among long-period enamel rhythms, the striae of Retzius, and body mass using a large sample of mammalian taxa. In addition, we test whether osteocyte lacuna density (a surrogate for rates of cell proliferation) in bone is correlated with mammalian body mass. Finally, using fluorescently labeled developing bone tissues, we investigate whether the bone lamella, a fundamental microanatomical unit of bone, relates to rhythmic enamel growth increments. Our results confirm a positive correlation between long-period enamel rhythms and body mass and a negative correlation between osteocyte density and body mass. We also confirm that lamellar bone is an incremental tissue, one lamella formed in the species-specific time dependency of striae of Retzius formation. We conclude by contextualizing our morphological research with a current understanding of autonomic regulatory control of the skeleton and body mass, suggesting a central contribution to the coordination of organismal life history and body mass.

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Endocrinology & Metabolism
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