Journal article
Language comprehension and regional cerebral defects in frontotemporal degeneration and Alzheimer's disease
Neurology, v 50(1), pp 157-163
Jan 1998
PMID: 9443473
Abstract
We related profiles of language comprehension difficulty to patterns of reduced cerebral functioning obtained with high-resolution single photon emission computed tomography (SPECT) in patients with neurodegenerative conditions. We found different patterns of reduced relative cerebral perfusion in patients with frontotemporal degeneration (FD) and patients with Alzheimer's disease (AD). Cognitive assessments also showed different patterns of impaired comprehension in patients with FD and patients with AD. Grammatical comprehension difficulty in FD correlated with relative cerebral perfusion in left frontal and anterior temporal brain regions; impaired semantic processing in AD correlated with relative cerebral perfusion in inferior parietal and superior temporal regions of the left hemisphere. These findings are consistent with the hypothesis that a neural network distributed throughout the left hemisphere subserving different aspects of language comprehension, rather than a single brain region, is responsible for understanding language.
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Details
- Title
- Language comprehension and regional cerebral defects in frontotemporal degeneration and Alzheimer's disease
- Creators
- M Grossman - University of PennsylvaniaF PayerK OnishiM D'EspositoD MorrisonA SadekA Alavi
- Publication Details
- Neurology, v 50(1), pp 157-163
- Grant note
- DC00039 / NIDCD NIH HHS NS01762 / NINDS NIH HHS AG09399 / NIA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000071486900029
- Scopus ID
- 2-s2.0-0031930761
- Other Identifier
- 991020929748404721
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- Web of Science research areas
- Clinical Neurology