Journal article
Large animal and primate models of spinal cord injury for the testing of novel therapies
Experimental neurology, v 269, pp 154-168
01 Jul 2015
PMID: 25902036
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Large animal and primate models of spinal cord injury (SCI) are being increasingly utilized for the testing of novel therapies. While these represent intermediary animal species between rodents and humans and offer the opportunity to pose unique research questions prior to clinical trials, the role that such large animal and primate models should play in the translational pipeline is unclear. In this initiative we engaged members of the SCI research community in a questionnaire and round-table focus group discussion around the use of such models. Forty-one SCI researchers from academia, industry, and granting agencies were asked to complete a questionnaire about their opinion regarding the use of large animal and primate models in the context of testing novel therapeutics. The questions centered around how large animal and primate models of SCI would be best utilized in the spectrum of preclinical testing, and how much testing in rodent models was warranted before employing these models. Further questions were posed at a focus group meeting attended by the respondents. The group generally felt that large animal and primate models of SCI serve a potentially useful role in the translational pipeline for novel therapies, and that the rational use of these models would depend on the type of therapy and specific research question being addressed. While testing within these models should not be mandatory, the detection of beneficial effects using these models lends additional support for translating a therapy to humans. These models provides an opportunity to evaluate and refine surgical procedures prior to use in humans, and safety and bio-distribution in a spinal cord more similar in size and anatomy to that of humans. Our results reveal that while many feel that these models are valuable in the testing of novel therapies, important questions remain unanswered about how they should be used and how data derived from them should be interpreted. (C) 2015 Elsevier Inc. All rights reserved.
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Details
- Title
- Large animal and primate models of spinal cord injury for the testing of novel therapies
- Creators
- Brian K. Kwon - University of British ColumbiaFemke Streijger - University of British ColumbiaCaitlin E. Hill - Cornell UniversityAileen J. Anderson - University of California, IrvineMark Bacon - Spinal ResearchMichael S. Beattie - University of California, San FranciscoArmin Blesch - Heidelberg UniversityElizabeth J. Bradbury - King's College LondonArthur Brown - Western UniversityJacqueline C. Bresnahan - University of California, San FranciscoCasey C. Case - Asterias BiotherapeuticsRaymond W. Colburn - Acorda TherapeuticsSamuel David - McGill UniversityJames W. Fawcett - University of CambridgeAdam R. Ferguson - University of California, San FranciscoItzhak Fischer - Drexel UniversityCandace L. Floyd - University of Alabama at BirminghamJohn C. Gensel - University of KentuckyJohn D. Houle - Drexel UniversityLyn B. Jakeman - National Institutes of HealthNick D. Jeffery - Iowa State UniversityLinda Ann Truett Jones - Craig H Neilsen Fdn, Encino, CA 91436 USANaomi Kleitman - Craig H Neilsen FoundationJeffery Kocsis - Yale UniversityPaul Lu - University of California, San DiegoDavid S. K. Magnuson - University of Louisville HospitalMartin Marsala - University of California, San DiegoSimon W. Moore - TiVoAndrea J. Mothe - Toronto Western HospitalMartin Oudega - University of Miami*Giles W. Plant - Stanford UniversityAlexander Sasha Rabchevsky - University of KentuckyJan M. Schwab - The Ohio State UniversityJerry Silver - Case Western Reserve UniversityOswald Steward - University of California, IrvineXiao-Ming Xu - Indiana UniversityJames D. Guest - University of Miami*Wolfram Tetzlaff - University of British Columbia
- Publication Details
- Experimental neurology, v 269, pp 154-168
- Publisher
- Elsevier
- Number of pages
- 15
- Grant note
- R01NS073857 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) EP/H00727X/1 / EPSRC; UK Research & Innovation (UKRI); Engineering & Physical Sciences Research Council (EPSRC) 17S71110 / Rick Hansen Foundation G1000864 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) G1000864 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission EP/H00727X/1 / Engineering and Physical Sciences Research Council; UK Research & Innovation (UKRI); Engineering & Physical Sciences Research Council (EPSRC)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000355640600015
- Scopus ID
- 2-s2.0-84928579017
- Other Identifier
- 991019169688804721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences