Journal article
Laryngeal Myasthenia Gravis: Report of 40 Cases
Journal of voice, v 15(1), pp 122-130
2001
PMID: 12269627
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Myasthenia gravis, an autoimmune disorder of the neuromuscular junction, is usually recognized because of ocular complaints or generalized weakness. We report a series of 40 patients who presented with dysphonia as their initial and primary complaint. Diagnostic testing included strobovideolaryngoscopy, electromyography (EMG) with repetitive stimulation and Tensilon testing, and laboratory and radiographic evaluation. Strobovideolaryngoscopy most commonly revealed fluctuating impairment of vocal fold mobility, either unilateral or bilateral. EMG detected evidence of neuromuscular junction abnormalities in all patients. Only one patient had evidence of antiacetylcholine receptor (ACh-R) antibodies, but many other abnormalities suggestive of autoimmune dysfunction were present. Pyridostigmine therapy was initiated in 34 patients but was not tolerated in 4. Of the remaining 30 patients, 23 reported improvement of symptoms. We conclude that myasthenia gravis can present with symptoms confined primarily to the larynx and should be included in the differential diagnosis of dysphonia.
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Details
- Title
- Laryngeal Myasthenia Gravis: Report of 40 Cases
- Creators
- Vivian H Mao - Thomas Jefferson UniversityMona Abaza - Thomas Jefferson UniversityJoseph R Spiegel - Thomas Jefferson UniversitySteven Mandel - Thomas Jefferson UniversityMary Hawkshaw - Thomas Jefferson UniversityReinhardt J Heuer - Thomas Jefferson UniversityRobert T Sataloff - Thomas Jefferson University
- Publication Details
- Journal of voice, v 15(1), pp 122-130
- Publisher
- Mosby, Inc
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Otolaryngology (and Head and Neck Surgery)
- Web of Science ID
- WOS:000167555300012
- Scopus ID
- 2-s2.0-0035080953
- Other Identifier
- 991019312338704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Audiology & Speech-language Pathology
- Otorhinolaryngology