Journal article
Laryngeal adenosquamous carcinoma: A population-based perspective
The Laryngoscope, v 126(4), pp 858-863
Apr 2016
PMID: 26452061
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives/HypothesisAdenosquamous carcinoma (ASC) is a rare entity, with fewer than 100 cases having been reported in the upper aerodigestive tract. Thus, no large samples characterizing its clinical behavior are available in the literature. Investigation of ASC has been further limited by difficulty in establishing histopathologic diagnosis. Our objective was to use a national population-based resource to evaluate patient demographics, clinical behavior, incidence, and survival for laryngeal adenosquamous carcinoma (LASC).
Study DesignRetrospective population-based analysis.
MethodsThe National Cancer Institute's Surveillance, Epidemiology, and End Results database was used to search for patients diagnosed with LASC between 1973 and 2012. Patient demographics, tumor characteristics, incidence, and survival trends were analyzed.
ResultsOf the 68 identified LASC patients, 79.4% were male and 20.6% were female. The mean age at diagnosis was 66.0 10.8 years. Whites represented 80.9% of patients, but no racial predominance was noted. LASC most commonly affected the glottis (47.1%), followed closely by the supraglottis (42.6%). Most cases were poorly differentiated (59.2%) and presented with stage IV disease (40.7%). Metastasis (M1) was noted in 10.7% of cases. The overall incidence was 0.003/100,000. The 5-year disease-specific survival rate was 36.6%, with a median observed survival of 33.6 months.
ConclusionsThis study notes that LASC has low overall incidence. It has a predilection for males, but does not demonstrate racial predominance. LASC tends to present with stage IV disease, with distant metastasis noted in approximately one in 10 cases. Overall prognosis is poor, with a median survival under 3 years.
Level of Evidence4 Laryngoscope, 126:858-863, 2016
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Details
- Title
- Laryngeal adenosquamous carcinoma: A population-based perspective
- Creators
- Pariket M. Dubal - Rutgers, The State University of New JerseyAykut A. Unsal - Rowan UniversityKristen A. Echanique - Rutgers, The State University of New JerseyAlejandro Vazquez - Rutgers, The State University of New JerseyLindsay S. Reder - University of Southern CaliforniaSoly Baredes - Rutgers, The State University of New JerseyJean Anderson Eloy - Rutgers, The State University of New Jersey
- Publication Details
- The Laryngoscope, v 126(4), pp 858-863
- Publisher
- Wiley
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Otolaryngology (and Head and Neck Surgery)
- Web of Science ID
- WOS:000373382100021
- Scopus ID
- 2-s2.0-84944062827
- Other Identifier
- 991021965461804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Otorhinolaryngology