Journal article
Laser Prophylaxis for Dry Age-Related Macular Degeneration: Current Evidence
Journal of clinical medicine, v 14(12), 4157
11 Jun 2025
PMID: 40565902
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Purpose: To review the role of prophylactic panmacular laser treatment for age-related macular degeneration (AMD). Method: A narrative review of studies employing laser treatment for non-exudative ("dry") AMD listed in the PubMed database. Results: In multiple published studies, macular laser treatment that causes laser-induced retinal damage (LIRD) has shown either no overall benefit or has accelerated disease progression and vision loss in eyes with dry AMD, particularly in high-risk eyes with more severe pre-treatment disease. Conversely, other studies, including randomized and matched propensity-scored real-world-data (RWD) clinical studies, indicate that avoidance of LIRD may allow laser to be used safely and effectively to prevent vision loss from AMD by slowing disease progression and preventing neovascular conversion without adverse treatment effects, benefiting the highest-risk eyes most. Conclusions: AMD is the leading cause of irreversible vision loss worldwide. Current evidence suggests that laser prophylaxis for dry AMD may hold great promise in preventing age-related vision loss. More studies, especially prospective clinical trials, from more investigators, are needed. If current evidence is confirmed, laser prophylaxis would rise to a preeminent position as the safest, most effective, and most economical and accessible approach to reducing vision loss from AMD.
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Details
- Title
- Laser Prophylaxis for Dry Age-Related Macular Degeneration: Current Evidence
- Creators
- Jeffrey K. Luttrull - Ventura County Medical CenterStephen H. Sinclair - Drexel UniversityIgor Kozak - University of Arizona
- Publication Details
- Journal of clinical medicine, v 14(12), 4157
- Publisher
- Mdpi
- Number of pages
- 18
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pennsylvania College of Optometry (PCO)
- Web of Science ID
- WOS:001516767700001
- Scopus ID
- 2-s2.0-105009076413
- Other Identifier
- 991022197313304721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Ophthalmology