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Journal article
Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct Precursors
The Journal of immunology (1950), v 193(10), pp 4971-4979
15 Nov 2014
PMID: 25326027
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Current models hold that serum Ab titers are maintained chiefly by long-lived bone marrow (BM) plasma cells (PCs). In this study, we characterize the role of subpopulations of BM PCs in long-term humoral responses to T cell-dependent Ag. Surprisingly, our results indicate that 40-50% of BM PCs are recently formed cells, defined, in part, by rapid steady-state turnover kinetics and secretion of low-affinity IgM Abs. Further, for months after immunization with a hapten-protein conjugate, newly formed Ag-induced, IgM-secreting BM PCs were detected in parallel with longer-lived IgG-secreting cells, suggesting ongoing and parallel input to the BM PC pool from two distinct pools of activated B cells. Consistent with this interpretation, IgM and IgG Abs secreted by cells within distinct PC subsets exhibited distinct L chain usage. We conclude that long-term Ab responses are maintained by a dynamic BM PC pool composed of both recently formed and long-lived PCs drawn from clonally disparate precursors.
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Details
- Title
- Lasting Antibody Responses Are Mediated by a Combination of Newly Formed and Established Bone Marrow Plasma Cells Drawn from Clonally Distinct Precursors
- Creators
- Irene Chernova - University of PennsylvaniaDerek D. Jones - University of PennsylvaniaJoel R. Wilmore - University of PennsylvaniaAlexandra Bortnick - University of PennsylvaniaMesut Yucel - Ege UniversityUri Hershberg - Drexel UniversityDavid Allman - University of Pennsylvania
- Publication Details
- The Journal of immunology (1950), v 193(10), pp 4971-4979
- Publisher
- American Association of Immunologists
- Number of pages
- 9
- Grant note
- R01AI097590 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) R01AI097590; F30HL112628; T32CA009140; T32 AI070099 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA F30HL112628 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) T32CA009140 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000345023400026
- Scopus ID
- 2-s2.0-84910115884
- Other Identifier
- 991019167714704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Immunology