Journal article
Late presentation of Takayasu arteritis in geriatric patients
Aging clinical and experimental research, v 32(2), pp 353-356
01 Feb 2020
PMID: 30993658
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Vasculitides are a heterogeneous group of potentially life-threatening diseases characterized by inflammation of blood vessels. The clinical features are dependent on the size and distribution of the vessels involved [1]. Takayasu arteritis (TA) is a granulomatous panarteritis of the aorta and its major branches, typically affecting young women during their reproductive years. TA can be divided into acute inflammatory and chronic healing phases and is classified according to the site of involvement: type I, only supra-aortic arteries; type IIa, only ascending aorta or aortic arch; type IIb, descending aorta with or without the more proximal portions of the aorta and aortic arch branches; type III, aortic arch and its branches with simultaneous involvement of the descending thoracic and abdominal portion or renal arteries; type IV, only abdominal aorta or renal arteries; and type V, generalized involvement as a combination of the other types [2]. Women are affected in 80–90% of cases, with an age of onset that is usually between 10 and 40 years. The initial vascular lesions frequently occur in the left middle or proximal subclavian artery. As the disease progresses, the left common carotid, vertebral, brachiocephalic, right middle, or proximal subclavian artery, right carotid, vertebral arteries, and aorta may also be affected. The abdominal aorta and pulmonary arteries are involved in approximately 50% of patients. The inflammatory process within the vessel can lead to narrowing, occlusion, or dilation of involved portions of the arteries, which causes a wide variety of symptoms. Giant cell arteritis (GCA) is a granulomatous vasculitis that targets large- and medium-sized arteries, most commonly affecting the aorta, branches of the ophthalmic artery, and extracranial branches of the carotid arteries. [1st paragraph]
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Details
- Title
- Late presentation of Takayasu arteritis in geriatric patients
- Creators
- Botros Shenoda - Drexel UniversityDaniel C. Sacher - Drexel UniversityElena Adamov - Drexel University
- Publication Details
- Aging clinical and experimental research, v 32(2), pp 353-356
- Publisher
- Springer Nature
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000514996100022
- Scopus ID
- 2-s2.0-85064557230
- Other Identifier
- 991021860774004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology