Journal article
Latent Class Analysis of Prenatal Substance Exposure and Child Behavioral Outcomes
The Journal of pediatrics, v 260, 113468
01 Sep 2023
PMID: 37182662
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
To predict behavioral disruptions in middle childhood, we identified latent classes of prenatal substance use.
As part of the Environmental influences on Child Health Outcomes Program, we harmonized prenatal substance use data and child behavior outcomes from 2195 women and their 6- to 11-year-old children across 10 cohorts in the US and used latent class–adjusted regression models to predict parent-rated child behavior.
Three latent classes fit the data: low use (90.5%; n = 1986), primarily using no substances; licit use (6.6%; n = 145), mainly using nicotine with a moderate likelihood of using alcohol and marijuana; and illicit use (2.9%; n = 64), predominantly using illicit substances along with a moderate likelihood of using licit substances. Children exposed to primarily licit substances in utero had greater levels of externalizing behavior than children exposed to low or no substances (P = .001, d = .64). Children exposed to illicit substances in utero showed small but significant elevations in internalizing behavior than children exposed to low or no substances (P < .001, d = .16).
The differences in prenatal polysubstance use may increase risk for specific childhood problem behaviors; however, child outcomes appeared comparably adverse for both licit and illicit polysubstance exposure. We highlight the need for similar multicohort, large-scale studies to examine childhood outcomes based on prenatal substance use profiles.
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Details
- Title
- Latent Class Analysis of Prenatal Substance Exposure and Child Behavioral Outcomes
- Creators
- Environmental influences on Child Health Outcomes (ECHO) (Collaboration)Sarah E. Maylott - Duke UniversityElisabeth Conradt - Duke UniversityMonica McGrath - Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MDEmily A. Knapp - Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MDXiuhong Li - Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MDRashelle Musci - Department of Mental Health, Johns Hopkins School of Public Health, Baltimore, MDJudy Aschner - Meridian (Russia)Lyndsay A. Avalos - Kaiser PermanenteLisa A. Croen - Kaiser PermanenteSean Deoni - Brown UniversityKaren Derefinko - University of Tennessee Health Science CenterAmy Elliott - University of South DakotaJulie A. Hofheimer - University of North Carolina at Chapel HillLeslie D. Leve - University of OregonJuliette C. Madan - Department of Pediatrics, Psychiatry and Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NHMaxwell Mansolf - Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, ILLiza B. Murrison - University of CincinnatiJenae M. Neiderhiser - Pennsylvania State UniversitySally Ozonoff - University of California, DavisJonathan Posner - Duke UniversityAmy Salisbury - Virginia Commonwealth UniversitySheela Sathyanarayana - University of WashingtonJulie B. Schweitzer - University of California, DavisCarl Seashore - University of North Carolina at Chapel HillMeagan E. Stabler - Department of Epidemiology, Dartmouth Geisel School of Medicine, Lebanon, NHLeslie W. Young - University of Vermont Medical CenterSteven J. Ondersma - Michigan State UniversityBarry Lester - Brown UniversityP.B. SmithK.L. NewbyL.P. JacobsonC.B. ParkerR. GershonD. CellaF.P. PereraJ.B. HerbstmanM.R. KaragasJ. GanibanA. FerraraN. PanethJ.M. KerverD.M. RudenV.A. D’SaC. BlairK.Z. LeWinnN.R. BushD. DabeleaM. O'SheaR. FryA. MasonJ.B. StanfordA. GiardinoC.A. PorucznikC. KarrS. SathyanarayanaJ. GernI. Hertz-PicciottoJ.B. SchweitzerD. Bennett
- Publication Details
- The Journal of pediatrics, v 260, 113468
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry
- Web of Science ID
- WOS:001028786400001
- Scopus ID
- 2-s2.0-85161715151
- Other Identifier
- 991020786008804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics