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Journal article
Latent inhibition effects reflected in event-related brain potentials in healthy controls and schizophrenics
Schizophrenia research, v 20(3), pp 315-326
1996
PMID: 8827859
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Abstract
The present study examined the effects of pre-exposure of an irrelevant stimulus on reaction time and the contingent negative variation (CNV) in healthy controls and schizophrenic patients. In Phase I, subjects were either pre-exposed (PE) or not pre-exposed (NPE) to repeated presentations of an auditory probe stimulus (white noise), while engaged in counting auditory nonsense syllables. In Phase II, all subjects were required to produce a rapid motor response to a visual imperative stimulus that was preceded by the previously irrelevant auditory stimulus. During Phase II in controls, for PE as compared to NPE subjects, the build-up of CNV across trials was delayed. In schizophrenics, for both PE and NPE subjects, there was no pre-exposure effect on the CNV component. These findings indicate that ERPs may be useful in explicating the normal latent inhibition effect (poor associative learning to a stimulus after it has been passively pre-exposed) and its disruption in schizophrenia.
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Details
- Title
- Latent inhibition effects reflected in event-related brain potentials in healthy controls and schizophrenics
- Creators
- Yossi Guterman - Max Stern Academic College of Emek YezreelRichard C. Josiassen - Norristown State HospitalTheodore E. Bashore - University of Northern ColoradoMichele Johnson - University of Pennsylvania, Philadelphia, PA 19104 USA;Robert E. Lubow - Tel Aviv University
- Publication Details
- Schizophrenia research, v 20(3), pp 315-326
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychiatry
- Web of Science ID
- WOS:A1996UY31900010
- Scopus ID
- 2-s2.0-0030570553
- Other Identifier
- 991019167733704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Psychiatry