Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism Clinical article
Journal of neurosurgery, v 119(1)
01 Jul 2013
PMID: 23560573
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Object. Deep brain stimulation (DBS) of the lateral hypothalamic area (LHA) has been suggested as a potential treatment for intractable obesity. The authors present the 2-year safety results as well as early efficacy and metabolic effects in 3 patients undergoing bilateral LHA DBS in the first study of this approach in humans.
Methods. Three patients meeting strict criteria for intractable obesity, including failed bariatric surgery, underwent bilateral implantation of LHA DBS electrodes as part of an institutional review board and FDA-approved pilot study. The primary focus of the study was safety; however, the authors also received approval to collect data on early efficacy including weight change and energy metabolism.
Results. No serious adverse effects, including detrimental psychological consequences, were observed with continuous LHA DBS after a mean follow-up of 35 months (range 30-39 months). Three-dimensional nonlinear transformation of postoperative imaging superimposed onto brain atlas anatomy was used to confirm and study DBS contact proximity to the LHA. No significant weight loss trends were seen when DBS was programmed using standard settings derived from movement disorder DBS surgery. However, promising weight loss trends have been observed when monopolar DBS stimulation has been applied via specific contacts found to increase the resting metabolic rate measured in a respiratory chamber.
Conclusions. Deep brain stimulation of the LHA may be applied safely to humans with intractable obesity. Early evidence for some weight loss under metabolically optimized settings provides the first "proof of principle" for this novel antiobesity strategy. A larger follow-up study focused on efficacy along with a more rigorous metabolic analysis is planned to further explore the benefits and therapeutic mechanism behind this investigational therapy.
Metrics
Details
- Title
- Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism Clinical article
- Creators
- Donald M. Whiting - Allegheny General HospitalNestor D. Tomycz - Allegheny General HospitalJulian Bailes - NorthShore University HealthSystemLilian de Jonge - National Institutes of HealthVirgile Lecoultre - Pennington Biomedical Research CenterBryan Wilent - Sentient ScienceDunbar Alcindor - Allegheny General HospitalE. Richard Prostko - Allegheny General HospitalBoyle C. Cheng - Allegheny General HospitalCynthia Angle - Allegheny General HospitalDiane Cantella - Allegheny General HospitalBenjamin B. Whiting - Allegheny General HospitalJ. Scott Mizes - West Virginia UniversityKirk W. Finnis - MedtronicEric Ravussin - Pennington Biomedical Research CenterMichael Y. Oh - Allegheny General Hospital
- Publication Details
- Journal of neurosurgery, v 119(1)
- Publisher
- Amer Assoc Neurological Surgeons
- Number of pages
- 8
- Grant note
- Medtronic Co. West Virginia University P30DK072476 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- SOM Dean - Research Administration; Surgery
- Web of Science ID
- WOS:000320739300015
- Scopus ID
- 2-s2.0-84879931488
- Other Identifier
- 991021448161604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Surgery