Journal article
Lead Extraction in the Contemporary Setting: The LExICon Study An Observational Retrospective Study of Consecutive Laser Lead Extractions
Journal of the American College of Cardiology, v 55(6), pp 579-586
09 Feb 2010
PMID: 20152562
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives This study sought to examine the safety and efficacy of laser-assisted lead extraction and the indications, outcomes, and risk factors in a large series of consecutive patients.
Background The need for lead extraction has been increasing in direct relationship to the increased numbers of cardiovascular implantable electronic devices.
Methods Consecutive patients undergoing transvenous laser-assisted lead extraction at 13 centers were included.
Results Between January 2004 and December 2007, 1,449 consecutive patients underwent laser-assisted lead extraction of 2,405 leads (20 to 270 procedures/site). Median implantation duration was 82.1 months (0.4 to 356.8 months). Leads were completely removed 96.5% of the time, with a 97.7% clinical success rate whereby clinical goals associated with the indication for lead removal were achieved. Failure to achieve clinical success was associated with body mass index <25 kg/m(2) and low extraction volume centers. Procedural failure was higher in leads implanted for >10 years and when performed in low volume centers. Major adverse events in 20 patients were directly related to the procedure (1.4%) including 4 deaths (0.28%). Major adverse effects were associated with patients with a body mass index <25 kg/m(2). Overall all-cause in-hospital mortality was 1.86%; 4.3% when associated with endocarditis, 7.9% when associated with endocarditis and diabetes, and 12.4% when associated with endocarditis and creatinine >= 2.0. Indicators of all-cause in-hospital mortality were pocket infections, device-related endocarditis, diabetes, and creatinine >= 2.0.
Conclusions Lead extraction employing laser sheaths is highly successful with a low procedural complication rate. Total mortality is substantially increased with pocket infections or device-related endocarditis, particularly in the setting of diabetes, renal insufficiency, or body mass index <25 kg/m(2). Centers with smaller case volumes tended to have a lower rate of successful extraction. (J Am Coll Cardiol 2010;55:579-86) (c) 2010 by the American College of Cardiology Foundation
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Details
- Title
- Lead Extraction in the Contemporary Setting: The LExICon Study An Observational Retrospective Study of Consecutive Laser Lead Extractions
- Creators
- Oussama Wazni - Cleveland ClinicLaurence M. Epstein - Harvard UniversityRoger G. Carrillo - Mount Sinai HospitalCharles Love - The Ohio State UniversityStuart W. Adler - United Heart and Vascular ClinicDavid W. Riggio - Arizona Heart HospitalShahzad S. Karim - University of British ColumbiaJamil Bashir - University of British ColumbiaArnold J. Greenspon - Thomas Jefferson UniversityJohn P. DiMarco - University of VirginiaJoshua M. Cooper - University of PennsylvaniaJohn R. Onufer - Cardiovascular Institute HospitalKenneth A. Ellenbogen - Virginia Commonwealth UniversityStephen P. Kutalek - Drexel UniversitySherri Dentry-Mabry - Spectranetics CorporationCarolyn M. Ervin - Spectranetics CorporationBruce L. Wilkoff - Cleveland ClinicSteven P Kutalek - College of Medicine (2002-)
- Publication Details
- Journal of the American College of Cardiology, v 55(6), pp 579-586
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- St. Jude Medical Medtronic Spectranetics Inc. Boston Scientific
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:000274232000009
- Scopus ID
- 2-s2.0-75249088559
- Other Identifier
- 991019339565904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems