Journal article
Left Ventricular Assist via Percutaneous Transhepatic Transseptal Cannulation in Swine
Catheterization and cardiovascular interventions, v 73(7), pp 961-965
01 Jun 2009
PMID: 19213076
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To report the in vivo testing of transhepatic, transseptal cannula insertion to support the left ventricle. Background: Percutaneous cannulation for circulatory assist poses particular challenges in pediatrics. We utilized a strategy using a transhepatic, transseptal venous cannula inserted into the left atrium, a centrifugal pump, and arterial cannula. Methods: Yorkshire swine of 5-20 kg (n = 6) were anesthetized for the procedure. After hepatic venous angiography, percutaneous puncture of the hepatic vein was performed, followed by transseptal puncture with echocardiographic guidance. A 10-14 Fr 26-cm venous inflow cannula was placed in the left atrium via hepatic approach. The femoral artery was cannulated with a 6-10 Fr femoral cannula, and the circuit completed with the TandemHeart centrifugal pump. Results: Implantation of the system utilizing the transhepatic approach was successful in all experiments. The pump delivered flows ranging from 0.8 to 1.4 L/min, which corresponded to 40-86% of the baseline systemic outputs. Decannulation and occlusion of the hepatic tract was successful utilizing transcatheter vascular occlusion plugs. Conclusion: The transhepatic, transseptal insertion of the inflow cannula, coupled with the TandemHeart centrifugal pump and femoral arterial cannulation allows percutaneous circulatory support in 5- to 20-kg models. (C) 2009 Wiley-Liss, Inc.
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Details
- Title
- Left Ventricular Assist via Percutaneous Transhepatic Transseptal Cannulation in Swine
- Creators
- D. Scott Lim - University of VirginiaCory J. Cortese - R&D and Engineering Department, CardiacAssist, Inc., Pittsburgh, PennsylvaniaAmber N. Loree - R&D and Engineering Department, CardiacAssist, Inc., Pittsburgh, PennsylvaniaDavid A. Dean - Drexel UniversityRobert G. Svitek - R&D and Engineering Department, CardiacAssist, Inc., Pittsburgh, PennsylvaniaChristos D Katsetos
- Publication Details
- Catheterization and cardiovascular interventions, v 73(7), pp 961-965
- Publisher
- Wiley
- Number of pages
- 5
- Grant note
- R44HL078077 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R44HL078077 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000266521000023
- Scopus ID
- 2-s2.0-68249133596
- Other Identifier
- 991019353718804721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems