Journal article
Lesioning Through a Directional Deep Brain Stimulation Lead in the Subthalamic Nucleus
Tremor and other hyperkinetic movements (New York, N.Y.), v 15(1), pp 1-6
07 Apr 2025
PMID: 40223941
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Clinical Vignette: A 59-year-old woman with a previous subthalamic nucleus deep brain stimulation (DBS) implanted for Parkinson's disease developed a hardware related infection. Clinical Dilemma: Wound dehiscence and infection developed and necessitated removal of the DBS system. The patient experienced excellent therapeutic benefit from her DBS and expressed concern about device removal. Clinical Solution: The patient was offered the option of a lesioning procedure which could be performed during hardware explantation. An operative procedure was conducted where the intracranial DBS lead was connected to a radiofrequency system in a deliberate effort to create a targeted subthalamotomy through the existing DBS lead. A multilevel lesion was generated using the contacts on the directional DBS lead. Following the lesion the DBS lead and hardware were removed. Gap in Knowledge: Creating a lesion through a DBS lead using radiofrequency ablation is a therapeutic option for patients not interested in later re-implantation or for those with a history of multiple DBS related infections. Lesioning through segmented leads introduces more complexity into the procedure.
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Details
- Title
- Lesioning Through a Directional Deep Brain Stimulation Lead in the Subthalamic Nucleus
- Creators
- Alfonso Enrique Martinez Nunez - University of FloridaDorian M. Kusyk - University of FloridaJoshua K. Wong - University of FloridaMichael S. Okun - University of FloridaJustin D. Hilliard - University of Florida
- Publication Details
- Tremor and other hyperkinetic movements (New York, N.Y.), v 15(1), pp 1-6
- Publisher
- Ubiquity Press Ltd
- Number of pages
- 6
- Grant note
- NIH, Parkinson's Foundation; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; Office of the Administrator (NIH) R25NS108939 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Michael J. Fox Foundation; Michael J Fox Foundation Parkinson Alliance Tourette Association of America Smallwood Foundation NIH, foundation R01 NS131342 NIH R01 NR014852; R01NS096008; UH3NS119844; U01NS119562 / UF Foundation WebMD/Medscape RMEI Medical Education
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:001470412100001
- Scopus ID
- 2-s2.0-105003513312
- Other Identifier
- 991022172858604721
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- Web of Science research areas
- Clinical Neurology