Journal article
Lesions of area postrema attenuate but do not prevent anorectic action of peripheral serotonin in rats
American journal of physiology. Regulatory, integrative and comparative physiology, v 269(6), pp R1314-R1320
01 Dec 1995
PMID: 8594931
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Abstract
These studies assessed the effect of selectively ablating the area postrema (AP) on the action of peripheral serotonin [5-hydroxytryptamine (5-HT)] to reduce food intake in rats. Intraperitoneal 5-HT (0, 2.0, 4.0, and 8.0 mumol/kg) reduced the intakes of sweetened mash during a 30-min test in controls (APC) and in AP-lesioned rats (APX). The anorexia was dose dependent in controls but the dose-response function was flat after AP lesions. In another study, 2.0 mumol/kg 5-HT reduced intakes of both groups by approximately 25%, but AP lesions blunted the effect at 8.0 mumol/kg 5-HT (APX, -30% vs. APC, -85%). Behavioral analysis revealed that, compared with controls, AP lesions eliminated the decrease in frequency of feeding and reduced the incidence of resting and of an aberrant posture observed after 8.0 mumol/kg. Thus peripheral 5-HT decreases food intake in rats with AP lesions. Multiple mechanisms appear to be involved in the ability of peripheral 5-HT to reduce feeding. A high dose of 5-HT promotes responses associated with satiation but also produces behavioral toxicity; these effects involve the AP. Lower doses appear to engage processes that do not rely on the function of this circumventricular organ.
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Details
- Title
- Lesions of area postrema attenuate but do not prevent anorectic action of peripheral serotonin in rats
- Creators
- V Adipudi - Department of Pharmacology, Medical College of Pennsylvania,Philadelphia, USAK. J Simansky - Department of Pharmacology, Medical College of Pennsylvania,Philadelphia, USA
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, v 269(6), pp R1314-R1320
- Publisher
- American Physiological Society (APS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:A1995TL96100004
- Scopus ID
- 2-s2.0-0029197750
- Other Identifier
- 991014878464304721
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- Web of Science research areas
- Physiology