Journal article
Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells
Tumor biology, v 36(8), pp 6383-6390
01 Aug 2015
PMID: 25833693
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Using yeast two-hybrid analysis, we identified several novel protein interactions for the oncoprotein Cancerous Inhibitor of PP2A (CIP2A) and confirmed a subset of these interactions in human cancer cell lines. Analysis of the interaction in prostate carcinoma cells between CIP2A and leucine-rich repeat-containing protein 59 (LRRC59) suggests that CIP2A is translocated into the nucleus at G2/M through its association with LRRC59. Recent work by others has demonstrated that nuclear CIP2A disrupts mitotic checkpoints, which promotes deregulation of the cell cycle and increases cancerous phenotypes. Thus, we provide a novel therapeutic mechanism for inhibiting CIP2A function in cancerous cells via targeting the CIP2A-LRRC59 interaction.
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Details
- Title
- Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells
- Creators
- Rajash Pallai - Medical Diagnostic Laboratories (United States)Aishwarya Bhaskar - Medical Diagnostic Laboratories (United States)Natalie Barnett-Bernodat - Medical Diagnostic Laboratories (United States)Christina Gallo-Ebert - AnsysMichelle Pusey - Medical Diagnostic Laboratories (United States)Joseph T. Nickels - AnsysLyndi M. Rice - Medical Diagnostic Laboratories (United States)
- Publication Details
- Tumor biology, v 36(8), pp 6383-6390
- Publisher
- Springer Netherlands
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000360193800076
- Scopus ID
- 2-s2.0-84940438000
- Other Identifier
- 991021229895904721
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- Web of Science research areas
- Oncology