Levels of p53 antigen in the plasma of patients with adenomas and carcinomas of the colon

Jiin-Chyuan Luo; Alfred I. Neugut; Gail Garbowski; Kenneth A. Forde; Michael Treat; Steven Smith; Walter P. Carney; Paul W. Brandt-Rauf

doi:10.1016/0304-3835(95)03744-H

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Levels of p53 antigen in the plasma of patients with adenomas and carcinomas of the colon

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Levels of p53 antigen in the plasma of patients with adenomas and carcinomas of the colon

Jiin-Chyuan Luo, Alfred I. Neugut, Gail Garbowski, Kenneth A. Forde, Michael Treat, Steven Smith, Walter P. Carney and Paul W. Brandt-Rauf

Cancer letters, v 91(2), pp 235-240

1995

DOI: https://doi.org/10.1016/0304-3835(95)03744-H

PMID: 7767914

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Abstract

Colonic adenomas

Colonic carcinomas

p53

Plasma biomarker

Plasma levels of p53 protein were examined by an enzyme linked immunosorbent assay in 184 patients enrolled in a colonoscopy study. The mean levels among 47 individuals with normal colonoscopic examinations and no prior history of colonic neoplasia (0.12 ng/ml) and among 61 individuals with normal colonoscopic examinations and a prior history of colonic neoplasia (0.09 ng/ml) were similar. However, the mean levels among 54 individuals with newly diagnosed colonic adenomas (0.44 ng/ml) and 22 individuals with newly diagnosed colonic carcinomas (0.55 ng/ml) were statistically significantly elevated compared to the normal controls ( P < 0.02). Among these tumor patients, the plasma levels tended to increase with increasing adenoma size and with increasing carcinoma stage, although these trends were not statistically significant. Defining a significant positive plasma level as any value greater than ten times background, the percentage of positive samples increased from 4% in the controls to 20% in the adenoma cases to 32% in the carcinoma cases. These results demonstrate that plasma p53 protein levels are elevated in a subgroup of individuals with colonic neoplasia.

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Title: Levels of p53 antigen in the plasma of patients with adenomas and carcinomas of the colon
Creators: Jiin-Chyuan Luo - Columbia University
Alfred I. Neugut - Columbia University
Gail Garbowski - Columbia University
Kenneth A. Forde - Columbia University
Michael Treat - Columbia University
Steven Smith - Columbia University
Walter P. Carney - Oncogene Sciences, Cambridge, MA 02142, USA
Paul W. Brandt-Rauf - Columbia University
Publication Details: Cancer letters, v 91(2), pp 235-240
Publisher: Elsevier Ireland Ltd
Resource Type: Journal article
Language: English
Academic Unit: School of Biomedical Engineering, Science, and Health Systems; Drexel University
Web of Science ID: WOS:A1995RA70500012
Scopus ID: 2-s2.0-0029046060
Other Identifier: 991019323668404721

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Web of Science research areas: Oncology

Levels of p53 antigen in the plasma of patients with adenomas and carcinomas of the colon

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