Journal article
Levels of the potential biomarker p11 in peripheral blood cells distinguish patients with PTSD from those with other major psychiatric disorders
Journal of psychiatric research, v 43(13), pp 1078-1085
2009
PMID: 19380152
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Posttraumatic stress disorder (PTSD) is a severely debilitating anxiety disorder. Over 80% of patients with PTSD also exhibit other psychiatric condition, such as bipolar disorder (BP) or major depression (MDD). Previously, it has been found that p11 mRNA expression was significantly changed in post mortem cortex of patients with PTSD and depression. We hypothesize that p11 mRNA levels in the peripheral blood cells will be a potential biomarker for PTSD with heterogeneity in terms of type of trauma, time since trauma and duration of illness. We examined the peripheral blood mononuclear cell (PBMC) P11 mRNA of patients with PTSD (
n
=
13), major depressive disorder (MDD,
n
=
16), bipolar disorder (BP,
n
=
24), and schizophrenia (SCZ,
n
=
12) or controls (
n
=
14) using quantitative real-time PCR and the circulating levels of cortisol in blood plasma and saliva of PTSD using radioimmunoassay kit CORT-CT2. The Hamilton Rating Scale for Depression (HAMD) and Anxiety (HARS), the Chinese version of the Davidson Trauma Scale-Frequency (CDTS-F) and the Chinese version of the Davidson Trauma Scale-Severity (CDTS-S), and Impact of Event Scale-Revised (IES-R) were administered. We found that patients with PTSD had lower levels of p11 mRNA than control subjects, while those with MDD, BP and SCZ had significantly higher p11 levels than the controls. P11 mRNA levels were positively correlated with the scores of HAMD (
r
=
0.62,
p
<
0.05), CDTS-F (
r
=
0.71,
p
<
0.05) and CDTS-S (
r
=
0.62,
p
<
0.05), while they did not correlate with scores of HARS and IES-R. Basal levels of plasma and salivary cortisol of PTSD patients were not statistically different from those of controls. Our findings suggest that PBMC p11 mRNA expression levels may serve as a potential biomarker to distinguish PTSD from BP, MDD and SCZ.
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Details
- Title
- Levels of the potential biomarker p11 in peripheral blood cells distinguish patients with PTSD from those with other major psychiatric disorders
- Creators
- Tung-Ping Su - Taipei Veterans General HospitalLei Zhang - Uniformed Services University of the Health SciencesMing-Yi Chung - National Yang-Ming UniversityYing-Sheue Chen - Taipei Veterans General HospitalYa-Mei Bi - Taipei Veterans General HospitalYuan-Hwa Chou - Taipei Veterans General HospitalJeffery L. Barker - National Institute of Neurological Disorders and StrokeJames E. Barrett - Drexel UniversityDragan Maric - National Institute of Neurological Disorders and StrokeXiao Xia Li - Uniformed Services University of the Health SciencesHe Li - Uniformed Services University of the Health SciencesMaree J. Webster - Stanley Medical Research InstituteDavid Benedek - Uniformed Services University of the Health SciencesJanis R. Carlton - Uniformed Services University of the Health SciencesRobert Ursano - Uniformed Services University of the Health Sciences
- Publication Details
- Journal of psychiatric research, v 43(13), pp 1078-1085
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000270624000004
- Scopus ID
- 2-s2.0-68949212300
- Other Identifier
- 991019169012504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Psychiatry