Journal article
Lifelong Consumption of Freeze-Dried Parabacteroides Distasonis Improves Gut Barrier Integrity and Extends Lifespan and Health Span in Drosophila Melanogaster
Aging and disease
22 Jun 2026
PMID: 42372240
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Chronic inflammation has been shown to be associated with aging. In Drosophila melanogaster, age-related inflammation in the gut results in a disruption of gut barrier integrity, which can lead to reduced intestinal function and death. The anaerobic bacterium Parabacteroides distasonis (Pd) has anti-inflammatory properties and can attenuate tumorigenesis and promote intestinal barrier integrity in a mouse model of colorectal cancer. Here, we show that administration of Pd to adult Drosophila significantly increases median lifespan and promotes maintenance of climbing ability throughout adult life. Furthermore, Pd supplementation enhances gut barrier integrity in aged adults. RNA-Seq analysis of adult gut tissue revealed that the elevated healthspan in Pd supplemented flies is accompanied by transcriptional upregulation of genes involved in DNA replication and maintenance of genome integrity. These results suggest that Pd supplementation may induce a transcriptional shift towards augmented DNA repair in the aging gut that prevents the breakdown of gut barrier integrity and promotes healthy aging.
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Details
- Title
- Lifelong Consumption of Freeze-Dried Parabacteroides Distasonis Improves Gut Barrier Integrity and Extends Lifespan and Health Span in Drosophila Melanogaster
- Creators
- Sarah Shnayder - Tufts UniversityVicki Do - Tufts UniversityJunyue Wang - Boston UniversityLuana Machado - Tufts UniversitySofia Rosa - Tufts UniversityLora Kusaku - Tufts UniversityBenjamin Kuo - Tufts UniversityJill Hutchinson - Tufts UniversityGrace Ogden - Tufts UniversityNeja Majeti - Drexel UniversityWeimin Guo - Boston UniversitySamuel Beck - Boston UniversityMitch McVey - Tufts UniversityJimmy W. Crott - Boston University
- Publication Details
- Aging and disease
- Publisher
- International Society for Aging & Disease
- Number of pages
- 13
- Grant note
- Healthy Aging at Tufts Initiative 58-8050-9-004 / USDA Agricultural Research Service Cooperative Agreement R01AG069917; NIH S10 OD 032203 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001806307800001
- Other Identifier
- 991022200099204721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology