Journal article
Lifestyle during pregnancy: Neurodevelopmental effects at 5 years of age. The design and implementation of a prospective follow-up study
Scandinavian journal of public health, v 38(2), pp 208-219
01 Mar 2010
PMID: 20064917
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background: It has been suggested that even mild exposure to alcohol, caffeine, smoking, and poor diet may have adverse long-term neurodevelopmental effects. In addition, there is evidence that timing of high exposures (e. g. binge drinking) can have particularly negative effects. This paper describes the design and implementation of The Lifestyle During Pregnancy Study addressing major methodological challenges for studies in this field. The study examines the effects of lifestyle during pregnancy on offspring neurodevelopment. Methods: In 2003, we initiated a prospective follow-up of 1750 mother-child pairs, sampled on the basis of maternal alcohol drinking patterns from The Danish National Birth Cohort (DNBC), a study of 101,042 pregnancies enrolled 1997-2003. Data collection in the DNBC involved four prenatal and postnatal maternal interviews, providing detailed information on maternal alcohol drinking patterns before and during pregnancy, caffeine intake, smoking, diet, and other lifestyle, medical, and sociodemographic factors. Results: At the age of 5 years, the children and their mothers participated in a comprehensive assessment of neurobehavioural development focusing on global cognition, specific cognitive functions, and behaviour. Two new tests assessing attention and speed of information processing among children were developed, and data on important potential confounders such as maternal intelligence quotient, vision, and hearing abilities were collected. Efforts were made to standardise procedures and obtain high inter-rater reliability. Conclusions: We expect that the study will illuminate the significance or lack of significance of maternal lifestyle during pregnancy and contribute to better understanding the effects of alcohol drinking during pregnancy at low to moderate consumption levels.
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Details
- Title
- Lifestyle during pregnancy: Neurodevelopmental effects at 5 years of age. The design and implementation of a prospective follow-up study
- Creators
- Ulrik Schioler Kesmodel - Univ Aarhus, Sch Publ Hlth, Dept Epidemiol, DK-8000 Aarhus C, DenmarkMette Underbjerg - Aarhus UniversityTina Rondrup Kilburn - Aarhus UniversityLeiv Bakketeig - University of Southern DenmarkErik Lykke Mortensen - University of CopenhagenNils Inge Landro - University of OsloDiana Schendel - Centers for Disease Control and PreventionJacquelyn Bertrand - Centers for Disease Control and PreventionJakob Grove - Aarhus UniversityShahul Ebrahim - Centers for Disease Control and PreventionPoul Thorsen - Emory University
- Publication Details
- Scandinavian journal of public health, v 38(2), pp 208-219
- Publisher
- Sage
- Number of pages
- 12
- Grant note
- Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA March of Dimes Birth Defects Foundation; March of Dimes Egmont Foundation Augustinus Foundation Lundbeck Foundation, Denmark; Lundbeckfonden Health Foundation Pharmacy Foundation Danish National Board of Health
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000274785700014
- Scopus ID
- 2-s2.0-77949321122
- Other Identifier
- 991021463603604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health