Journal article
Light-Patterned RNA Interference of 3D-Cultured Human Embryonic Stem Cells
Advanced materials (Weinheim), v 28(48), pp 10732-10737
01 Dec 2016
PMID: 27787919
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A new method of spatially controlled gene regulation in 3D-cultured human embryonic stem cells is developed using hollow gold nanoshells (HGNs) and near-infrared (NIR) light. Targeted cell(s) are discriminated from neighboring cell(s) by focusing NIR light emitted from a two-photon microscope. Irradiation of cells that have internalized HGNs releases surface attached siRNAs and leads to concomitant gene downregulation.
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Details
- Title
- Light-Patterned RNA Interference of 3D-Cultured Human Embryonic Stem Cells
- Creators
- Xiao Huang - University of California, Santa BarbaraQirui Hu - University of California, Santa BarbaraYifan Lai - University of California, Santa BarbaraDemosthenes P. Morales - University of California, Santa BarbaraDennis O. Clegg - University of California, Santa BarbaraNorbert O. Reich - University of California, Santa Barbara
- Publication Details
- Advanced materials (Weinheim), v 28(48), pp 10732-10737
- Publisher
- Wiley
- Number of pages
- 7
- Grant note
- TG2-01151 / California Institute for Regenerative Medicine (CIRM); California Institute for Regenerative Medicine S10RR022585 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA CL1-00521 / CIRM; California Institute for Regenerative Medicine 2011674001 / Chinese Scholarship Council (CSC); China Scholarship Council R01 EB012637 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000392728200018
- Scopus ID
- 2-s2.0-84997207105
- Other Identifier
- 991022130762704721
UN Sustainable Development Goals (SDGs)
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Multidisciplinary
- Chemistry, Physical
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology
- Physics, Applied
- Physics, Condensed Matter