Journal article
Limitations of the rat medial forebrain lesion model to study prefrontal cortex mediated cognitive tasks in Parkinson’s disease
Brain research, v 1702, pp 105-113
01 Jan 2019
PMID: 29608880
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•A 6-OHDA induced medial forebrain bundle lesion rodent model of Parkinson’s Disease (PD): Produces stable and robust motor impairment in rodents.•Impairments in the simple discrimination task of attentional set shifting paradigm.•Produces temporal order memory deficits, but not in spatially-driven object recognition task.•No difference between male and female rats in cognitive flexibility and memory tasks.•Does not recapitulate the PFC-mediated cognitive deficits observed in PD patients.
Parkinson’s Disease (PD) is a progressive movement disorder characterized by the loss of dopaminergic neurons in the midbrain. Besides motor impairment, PD patients exhibit non-motor symptoms that negatively impact their quality of life and often manifest prior to motor deficits. One such symptom is mild cognitive impairment (PD-MCI), which is comprised of deficits in executive function such as working memory, attention, cognitive flexibility, and spatial memory. The 6-hydroxydopamine (6-OHDA) induced unilateral medial forebrain bundle (MFB) lesion animal model successfully recapitulates PD motor impairment but is also used to assess non-motor deficits. The present study utilizes a unilateral 6-OHDA induced MFB lesion rodent model to investigate prefrontal cortex (PFC)-mediated cognitive processes that are impaired in PD patients. In a test of attentional set shifting, PD rodents demonstrated deficits in simple discrimination, but not in rule reversal or extradimensional shifts. PD rodents also exhibited deficits in a temporal order memory task but had no deficits in novel/spatial object recognition or object-in-place tasks. These results reveal limitations of the 6-OHDA induced unilateral MFB lesion model to completely recapitulate PD-MCI symptoms suggesting a need for better lesion models to study PD-MCI.
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Details
- Title
- Limitations of the rat medial forebrain lesion model to study prefrontal cortex mediated cognitive tasks in Parkinson’s disease
- Creators
- Courtney A. Marshall - Drexel UniversityKirsten M. King - Drexel UniversitySandhya Kortagere - Drexel University
- Publication Details
- Brain research, v 1702, pp 105-113
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000454370800012
- Scopus ID
- 2-s2.0-85045556789
- Other Identifier
- 991019167728204721
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- Web of Science research areas
- Neurosciences