Journal article
Limited generalizability of dynamic fMRI correlates of adolescent rumination
Nature mental health, v 3(11), pp 1407-1416
20 Oct 2025
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Rumination, or perseverative negative self-referential thinking, is a hallmark of depression. In adults, a dynamic resting-state functional magnetic resonance imaging model of trait rumination was recently identified through predictive modeling. In adolescents, a development period during which rumination and depression increase, the neurobiological correlates of ruminative thinking are less clear. Here, in the current preregistered study, we examine dynamic connectivity correlates of self-reported rumination in a large sample of adolescents (n = 443, containing clinical and nonclinical individuals). Notably, the adult model failed to generalize to our sample. In addition, linear models trained on default-mode network (DMN) connectivity, as well as whole-brain connectome models, failed to generalize to held-out data. In an exploratory random forest analysis, we found significant prediction performance of a model in which increased variability between DMN-cerebellum, DMN-dorsal attention network and DMN-DMN connections was nominally associated with higher rumination. However, the model did not generalize to an external sample with lower rumination scores and a distinct scanner protocol. Our findings illustrate the difficulty of characterizing the neurodevelopment of risk factors for depression.
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Details
- Title
- Limited generalizability of dynamic fMRI correlates of adolescent rumination
- Creators
- Isaac N. Treves - McGovern Institute for Brain ResearchMadelynn S. Park - Massachusetts Institute of TechnologyJamaal Spence - New York State Psychiatric InstituteNigel Jaffe - McLean HospitalKristina Pidvirny - McLean HospitalAnna O. Tierney - Harvard UniversityAaron K. Kucyi - Drexel University, Psychological and Brain Sciences (Psychology)John D. E. Gabrieli - Center for Autism and Related DisordersRandy P. Auerbach - Columbia UniversityChristian A. Webb - Harvard University
- Publication Details
- Nature mental health, v 3(11), pp 1407-1416
- Publisher
- Springer Nature
- Number of pages
- 19
- Grant note
- Klingenstein Third Generation Foundation; Klingenstein Philanthropies NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01AT011002 / Dana Foundation (Charles A. Dana Foundation) Dana Foundation Brain & Behavior Research Foundation; NARSAD Tommy Fuss Fund R01MH116969; K23MH108752 / NCCIH
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:001596202400001
- Scopus ID
- 2-s2.0-105019177500
- Other Identifier
- 991022127348404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Psychiatry