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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Limiting tumor seeding as a therapeutic approach for metastatic disease
Pharmacology & therapeutics (Oxford), v 199, pp 117-128
Jul 2019
PMID: 30877019
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Here we propose that therapeutic targeting of circulating tumor cells (CTCs), which are widely understood to be the seeds of metastasis, would represent an effective strategy towards limiting numerical expansion of secondary lesions and containing overall tumor burden in cancer patients. However, the molecular mediators of tumor seeding have not been well characterized. This is in part due to the limited number of pre-clinical in vivo approaches that appropriately interrogate the mechanisms by which cancer cells home to arresting organs. It is critical that we continue to investigate the mediators of tumor seeding as it is evident that the ability of CTCs to colonize in distant sites is what drives disease progression even after the primary tumor has been ablated by local modalities. In addition to slowing disease progression, containing metastatic spread by impeding tumor cell seeding may also provide a clinical benefit by increasing the duration of the residence of CTCs in systemic circulation thereby increasing their exposure to pharmacological agents commonly used in the treatment of patients such as chemotherapy and immunotherapies. In this review we will examine the current state of knowledge about the mechanisms of tumor cells seeding as well as explore how targeting this stage of metastatic spreading may provide therapeutic benefit to patients with advanced disease.
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Details
- Title
- Limiting tumor seeding as a therapeutic approach for metastatic disease
- Creators
- Asurayya Worrede - Drexel UniversityOlimpia Meucci - Drexel UniversityAlessandro Fatatis - Drexel University
- Publication Details
- Pharmacology & therapeutics (Oxford), v 199, pp 117-128
- Publisher
- Elsevier
- Grant note
- R01 CA202929 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000474321600007
- Scopus ID
- 2-s2.0-85063062835
- Other Identifier
- 991019167780804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy