Journal article
Linear Relationships Between Total Hydrocarbons and Benzene, Toluene, Ethylbenzene, Xylene, and n-Hexane during the Deepwater Horizon Response and Clean-up
Annals of work exposures and health, v 66(Suppl 1), pp i71-i88
02 Sep 2021
PMID: 34473212
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives Our objectives were to (i) determine correlations between measurements of THC and of BTEX-H, (ii) apply these linear relationships to predict BTEX-H from measured THC, (iii) use these correlations as informative priors in Bayesian analyses to estimate exposures. Methods We used a Bayesian left-censored bivariate framework for all 3 objectives. First, we modeled the relationships (i.e. correlations) between THC and each BTEX-H chemical for various overarching groups of measurements using linear regression to determine if correlations derived from linear relationships differed by various exposure determinants. We then used the same linear regression relationships to predict (or impute) BTEX-H measurements from THC when only THC measurements were available. Finally, we used the same linear relationships as priors for the final exposure models that used real and predicted data to develop exposure estimate statistics for each individual exposure group. Results Correlations between measurements of THC and each of the BTEX-H chemicals (n = 120 for each of BTEX, 36 for n-hexane) differed substantially by area of the Gulf of Mexico and by time period that reflected different oil-spill related exposure opportunities. The correlations generally exceeded 0.5. Use of regression relationships to impute missing data resulted in the addition of >23 000 n-hexane and 541 observations for each of BTEX. The relationships were then used as priors for the calculation of exposure statistics while accounting for censored measurement data. Conclusions Taking advantage of observed relationships between THC and BTEX-H allowed us to develop robust exposure estimates where a large amount of data were missing, strengthening our exposure estimation process for the epidemiologic study.
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Details
- Title
- Linear Relationships Between Total Hydrocarbons and Benzene, Toluene, Ethylbenzene, Xylene, and n-Hexane during the Deepwater Horizon Response and Clean-up
- Creators
- Caroline P. Groth - Department of Epidemiology and Biostatistics, WVU School of Public Health, West Virginia University, One Medical Center Drive, Morgantown, WV, USATran B. Huynh - Drexel UniversitySudipto Banerjee - University of California, Los AngelesGurumurthy Ramachandran - BloombergPatricia A. Stewart - Stewart Exposure Assessments, LLC, 6045 N. 27th. St., Arlington, VA 22207, USA.Harrison Quick - Drexel UniversityDale P. Sandler - National Institute of Environmental Health SciencesAaron Blair - National Cancer InstituteLawrence S. Engel - University of North Carolina at Chapel HillRichard K. Kwok - Office of the DirectorMark R. Stenzel - Exposure Assessment Applications, LLC, 6045 N. 27th. St., Arlington, VA 22207, USA.
- Publication Details
- Annals of work exposures and health, v 66(Suppl 1), pp i71-i88
- Publisher
- Oxford Univ Press
- Number of pages
- 18
- Grant note
- NIH Common Fund; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA K01OH011191 / Center for Disease Control/National Institute for Occupational Safety and Health; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA; National Institute for Occupational Safety & Health (NIOSH) DMS-1513654; IIS-1562303; DMS-1916349 / National Science Foundation; National Science Foundation (NSF) ZO1ES102945 / Intramural Research Program of the NIH, National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) R01ES027027-01; R01ES030210-01 / National Institutes of Health/National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics; Environmental and Occupational Health
- Web of Science ID
- WOS:000756406600001
- Scopus ID
- 2-s2.0-85128249108
- Other Identifier
- 991019168486804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health