Journal article
Lipid profiles of patients with manifest coronary versus peripheral atherosclerosis - is there a difference?
JOURNAL OF INTERNAL MEDICINE, v 290(6), pp 1249-1263
Dec 2021
PMID: 34337800
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aim Peripheral arterial disease (PAD) and coronary artery disease (CAD) are both caused by atherosclerosis. Serum lipids and lipoproteins are predictive of the development of atherosclerosis but it is not clear if they differ in the two manifestations PAD and CAD. We tested whether a more detailed characterization of the lipid and lipoprotein patterns of PAD and CAD allows a clear differentiation between the two atherosclerotic phenotypes. Methods A cohort of 274 statin-naive patients with either newly diagnosed imaging proven PAD (n = 89) or stable CAD (n = 185) was characterized using nuclear magnetic resonance- and liquid chromatography-tandem mass spectrometry-based advanced lipid and lipoprotein analysis. An independent cohort of 1239 patients with PAD and CAD was used for validation. Results We found a significant difference in markers of inflammation as well as ceramide and phosphatidylcholine levels between PAD and CAD patients. In contrast, basic lipid markers including total cholesterol, LDL cholesterol, HDL cholesterol, lipoprotein(a) or detailed lipoprotein profiles did not differ significantly between PAD and CAD patients. Applying ratios and scores derived from ceramides and phosphatidylcholines further improved the discrimination between PAD and CAD. These significant differences were independent of body composition, from the status of smoking or T2DM, and also from apolipoprotein C-III and other inflammatory parameters which were different between CAD and PAD. Conclusion The present study clearly suggests that PAD and CAD differ in terms of their ceramide- and phosphatidylcholine-based lipid patterns but not in lipoprotein characteristics.
Metrics
Details
- Title
- Lipid profiles of patients with manifest coronary versus peripheral atherosclerosis - is there a difference?
- Publication Details
- JOURNAL OF INTERNAL MEDICINE, v 290(6), pp 1249-1263
- Publisher
- WILEY; HOBOKEN
- Number of pages
- 14
- Grant note
- We are grateful to the Vorarlberger Landesregierung (Bregenz, Austria) for continuously supporting our research institute and to Prof. Iris Baumgartner (Clinic of Angiology, University Hospital of Bern, Switzerland) for sponsoring NMR analysis. Apart from that, the present study did not receive any further financial support or grant from funding agencies in the public, commercial, or not-for-profit sectors.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000695044500001
- Scopus ID
- 2-s2.0-85114610506
- Other Identifier
- 991021860755704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems