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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Liquid biopsies for hepatocellular carcinoma
Translational research : the journal of laboratory and clinical medicine, v 201, pp 84-97
01 Nov 2018
PMID: 30056068
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Hepatocellular carcinoma (HCC) is the world's second leading cause of cancer death; 82.4% of patients die within 5 years. This grim prognosis is the consequence of a lack of effective early detection tools, limited treatment options, and the high frequency of HCC recurrence. Advances in the field of liquid biopsy hold great promise in improving early detection of HCC, advancing patient prognosis, and ultimately increasing the survival rate. In an effort to address the current challenges of HCC screening and management, several studies have identified and evaluated liver-cancer-associated molecular signatures such as genetic alterations, methylation, and noncoding RNA expression in the form of circulating biomarkers in body fluids and circulating tumor cells of HCC patients. In this review, we summarize the recent progress in HCC liquid biopsy, organized by the intended clinical application of the reported study.
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Details
- Title
- Liquid biopsies for hepatocellular carcinoma
- Creators
- Ying-Hsiu Su - Baruch S. Blumberg InstituteAmy K Kim - Johns Hopkins MedicineSurbhi Jain - JBS Science (United States)
- Publication Details
- Translational research : the journal of laboratory and clinical medicine, v 201, pp 84-97
- Publisher
- Elsevier
- Grant note
- R43 CA213610 / NCI NIH HHS R44 CA165312 / NCI NIH HHS R01 CA202769 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000449037200008
- Scopus ID
- 2-s2.0-85050848942
- Other Identifier
- 991021463576404721
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- Web of Science research areas
- Medical Laboratory Technology
- Medicine, Research & Experimental