Journal article
Lissencephaly-Pachygyria Associated With Congenital Cytomegalovirus Infection
Journal of child neurology, v 6(2), pp 109-114
01 Apr 1991
PMID: 1646253
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Abstract
We report the presence of major cerebral migrational defects in five severely, multiply handicapped children with congenital cytomegalovirus (CMV) infection. These patients had both computed tomographic (CT) scan and magnetic resonance imaging (MRI) evidence of marked migrational central nervous system defects consistent anatomically with the spectrum of lissencephaly-pachygyria, a disorder commonly idiopathic or associated with chromosomal abnormalities or with unknown early gestational insults. Neuroradiologic features included broad, flat gyri, shallow sulci, incomplete opercularization, ventriculomegaly, periventricular calcifications, and white-matter hypodensity on CT scans or increased signal intensity on long-TR MRI scans. Evidence for congenital CMV infection included prenatal onset of microcephaly, periventricular calcifications, neonatal jaundice, hepatomegaly, elevated CMV-specific immunoglobulin M, or viral isolation from urine. Previous reports of the neurologic sequelae of CMV have emphasized varying degrees of psychomotor retardation, cerebral palsy and epilepsy due to polymicrogyria, periventricular calcification, microcephaly, or rarely, hydrocephalus. Our patients appear to represent extremely severe examples of the effects of CMV on neurologic growth, maturation, and development. Recognition of these severe migrational abnormalities was improved by use of MRI, a technique that affords superior definition of the nature and extent of gyral and white-matter abnormalities. We suggest that these abnormalities may be more common than has previously been recognized. ( J Child Neurol 1991;6:109-114).
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Details
- Title
- Lissencephaly-Pachygyria Associated With Congenital Cytomegalovirus Infection
- Creators
- Jean C. Hayward - Children's Hospital of PhiladelphiaDavid S. Titelbaum - University of PennsylvaniaRobert R. Clancy - Children's Hospital of PhiladelphiaRobert A. Zimmerman - University of Pennsylvania
- Publication Details
- Journal of child neurology, v 6(2), pp 109-114
- Publisher
- Sage
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:A1991FE58600003
- Scopus ID
- 2-s2.0-0025852593
- Other Identifier
- 991021838608604721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Clinical Neurology
- Pediatrics