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Journal article
Liver-Specific MicroRNA miR-122 Enhances the Replication of Hepatitis C Virus in Nonhepatic Cells
Journal of virology, v 82(16), pp 8215-8223
11 Jun 2008
PMID: 18550664
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The liver-specific microRNA miR-122 has been shown to be required for the replication of hepatitis C virus (HCV) in the hepatoma cell line Huh7. The aim of this study was to test if HCV replication can be modulated by exogenously expressed miR-122 in human embryonic kidney epithelial cells (HEK-293). Our results demonstrate that miR-122 enhances the colony formation efficiency of the HCV replicon and increases the steady-state level of HCV RNA in HEK-293 cells. Therefore, we conclude that although miR-122 is not absolutely required, it greatly enhances HCV replication in nonhepatic cells.
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Details
- Title
- Liver-Specific MicroRNA miR-122 Enhances the Replication of Hepatitis C Virus in Nonhepatic Cells
- Creators
- Jinhong Chang - Drexel UniversityJu-Tao Guo - Drexel UniversityDong Jiang - Drexel UniversityHaitao Guo - Drexel UniversityJohn M. Taylor - Fox Chase Cancer CenterTimothy M. Block - Drexel University
- Publication Details
- Journal of virology, v 82(16), pp 8215-8223
- Publisher
- American Society for Microbiology (ASM)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000258166500045
- Scopus ID
- 2-s2.0-49149121957
- Other Identifier
- 991019169523204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Virology