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Journal article
Liver-Targeting Nanoplatforms for the Induction of Immune Tolerance
Nanomaterials (Basel, Switzerland), v 14(1), 67
26 Dec 2023
PMID: 38202522
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Liver-targeting nanoparticles have emerged as a promising platform for the induction of immune tolerance by taking advantage of the liver's unique tolerogenic properties and nanoparticles' physicochemical flexibility. Such an approach provides a versatile solution to the treatment of a diversity of immunologic diseases. In this review, we begin by assessing the design parameters integral to cell-specific targeting and the tolerogenic induction of nanoplatforms engineered to target the four critical immunogenic hepatic cells, including liver sinusoidal epithelial cells (LSECs), Kupffer cells (KCs), hepatic stellate cells (HSCs), and hepatocytes. We also include an overview of multiple therapeutic strategies in which nanoparticles are being studied to treat many allergies and autoimmune disorders. Finally, we explore the challenges of using nanoparticles in this field while highlighting future avenues to expand the therapeutic utility of liver-targeting nanoparticles in autoimmune processes.
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Details
- Title
- Liver-Targeting Nanoplatforms for the Induction of Immune Tolerance
- Creators
- Sydney Kusumoputro - Drexel University, College of MedicineChristian Au - University of Southern CaliforniaKatie H. Lam - University of Southern CaliforniaNathaniel Park - Drexel Univ, Dept Med, Coll Med, Philadelphia, PA 19129 USAAustin Hyun - Lake Erie College of Osteopathic MedicineEmily Kusumoputro - University of California, RiversideXiang Wang - Univ Calif Los Angeles, Dept Med, Div Nanomed, Los Angeles, CA 90095 USATian Xia - Univ Calif Los Angeles, Dept Med, Div Nanomed, Los Angeles, CA 90095 USA
- Publication Details
- Nanomaterials (Basel, Switzerland), v 14(1), 67
- Publisher
- Mdpi
- Number of pages
- 30
- Grant note
- California NanoSystems Institute, University of California Los Angeles
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001140329300001
- Scopus ID
- 2-s2.0-85181889063
- Other Identifier
- 991022005885204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Chemistry, Multidisciplinary
- Materials Science, Multidisciplinary
- Nanoscience & Nanotechnology
- Physics, Applied