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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Living Near Major Traffic Roads and Risk of Deep Vein Thrombosis
Circulation (New York, N.Y.), v 119(24), pp 3118-3124
23 Jun 2009
PMID: 19506111
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background-Particulate air pollution has been consistently linked to increased risk of arterial cardiovascular disease. Few data on air pollution exposure and risk of venous thrombosis are available. We investigated whether living near major traffic roads increases the risk of deep vein thrombosis (DVT), using distance from roads as a proxy for traffic exposure.
Methods and Results-From 1995 through 2005, we examined 663 patients with DVT of the lower limbs and 859 age-matched controls from cities with population > 15 000 inhabitants in Lombardia Region, Italy. We assessed distance from residential addresses to the nearest major traffic road using geographic information system methodology. The risk of DVT was estimated from logistic regression models adjusting for multiple clinical and environmental covariates. The risk of DVT was increased (odds ratio = 1.33; 95% confidence interval, 1.03 to 1.71; P = 0.03 in age-adjusted models; odds ratio = 1.47; 95% confidence interval, 1.10 to 1.96; P = 0.008 in models adjusted for multiple covariates) for subjects living near a major traffic road (index distance of 3 meters, 10th centile of the distance distribution) compared with those living farther away (reference distance of 245 meters, 90th centile). The increase in DVT risk was approximately linear over the observed distance range (from 718 to 0 meters) and was not modified after adjusting for background levels of particulate matter (odds ratio = 1.47; 95% confidence interval, 1.11 to 1.96; P = 0.008 for 10th versus 90th distance centile in models adjusting for area levels of particulate matter < 10 mu m in aerodynamic diameter in the year before diagnosis).
Conclusions-Living near major traffic roads is associated with increased risk of DVT. (Circulation. 2009; 119: 3118-3124.)
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Details
- Title
- Living Near Major Traffic Roads and Risk of Deep Vein Thrombosis
- Creators
- Andrea Baccarelli - Ospedale MaggioreIda Martinelli - Ospedale MaggioreValeria Pegoraro - Ospedale MaggioreSteven Melly - Ospedale MaggiorePaolo Grillo - Ospedale MaggioreAntonella Zanobetti - Ospedale MaggioreLifang Hou - Ospedale MaggiorePier Alberto Bertazzi - Ospedale MaggiorePier Mannuccio Mannucci - Ospedale MaggioreJoel Schwartz - Ospedale Maggiore
- Publication Details
- Circulation (New York, N.Y.), v 119(24), pp 3118-3124
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 7
- Grant note
- R-82735301 / US Environmental Protection Agency; United States Environmental Protection Agency ES0002; ES015172-01 / US National Institute of Environmental Health Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) 2007-2S2HT8 / Italian Ministry of Scientific Research-Programs of Scientific Research of Relevant National Interest (PRIN); Ministry of Education, Universities and Research (MIUR); Research Projects of National Relevance (PRIN) R01ES015172 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) Cassa di Risparmio delle Province Lombarde (CARIPLO) Foundation; Fondazione Cariplo
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000267279900012
- Scopus ID
- 2-s2.0-67649563006
- Other Identifier
- 991021875476204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Peripheral Vascular Disease