Files and links (1)
Published, Version of Record (VoR)CC BY-NC-SA V4.0, Open
Journal article
Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation
The Journal of experimental medicine, v 211(1), pp 45-56
13 Jan 2014
PMID: 24367004
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We have assessed the role of B lymphocyte stimulator (BLyS) and its receptors in the germinal center (GC) reaction and affinity maturation. Despite ample BLyS retention on B cells in follicular (FO) regions, the GC microenvironment lacks substantial BLyS. This reflects IL-21-mediated down-regulation of the BLyS receptor TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) on GC B cells, thus limiting their capacity for BLyS binding and retention. Within the GC, FO helper T cells (TFH cells) provide a local source of BLyS. Whereas T cell-derived BLyS is dispensable for normal GC cellularity and somatic hypermutation, it is required for the efficient selection of high affinity GC B cell clones. These findings suggest that during affinity maturation, high affinity clones rely on TFH-derived BLyS for their persistence.
Metrics
Details
- Title
- Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation
- Creators
- Radhika Goenka - University of PennsylvaniaAndrew H. Matthews - University of PennsylvaniaBochao Zhang - Drexel UniversityPatrick J. O'Neill - University of PennsylvaniaJean L. Scholz - University of PennsylvaniaThi-Sau Migone - Human Genome SciencesWarren J. Leonard - National Heart Lung and Blood InstituteWilliam Stohl - University of Southern CaliforniaUri Hershberg - Drexel UniversityMichael P. Cancro - University of Pennsylvania
- Publication Details
- The Journal of experimental medicine, v 211(1), pp 45-56
- Publisher
- Rockefeller Univ Press
- Number of pages
- 12
- Grant note
- ZIAHL005408 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Human Genome Sciences, Inc. P30CA016520 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) AI073939; AR050193 / National Institutes of Health [NIH]; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01AR050193 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01AI073939 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000329793300005
- Scopus ID
- 2-s2.0-84892546134
- Other Identifier
- 991019167434704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Immunology
- Medicine, Research & Experimental