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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Local administration of a cannabinoid agonist alters norepinephrine efflux in the rat frontal cortex
Neuroscience letters, v 431(1), pp 1-5
24 Jan 2008
PMID: 18055114
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Delta(9)-Tetrahydrocannabinol, the main psychoactive ingredient in marijuana, activates specific cannabinoid (CB) receptors to exert complex actions on modulatory neurotransmitters involved in attention and cognition. Previous research has demonstrated that systemic administration of the synthetic cannabinoid agonist, WIN55,212-2, increases norepinephrine efflux in the frontal cortex. The distribution of CB1 receptors on noradrenergic fibers in the frontal cortex suggests this may be one potential site for the regulation of norepinephrine release. In the present study, we first examined the ability of a CB1 antagonist, applied locally in the frontal cortex of adult male Sprague-Dawley rats, to block the actions of systemic WIN 55,212-2. Pretreatment with SR 141716A (300 mu M) significantly attenuated the excitatory effects of WIN 55,212-2 (15 mg/kg, i.p.). Next, the impact of direct perfusion of WIN 55,212-2 into the frontal cortex on extracellular norepinephrine efflux was measured. Direct application of WIN 55,212-2 (100 mu M) into the frontal cortex elicited a significant increase in extracellular norepinephrine efflux suggesting that activation of cortical cannabinoid receptors contributes to alterations in norepinephrine levels in this brain region. Finally, local administration of SR 141716A followed by local administration of WIN 55,212-2 revealed a paradoxical inhibition of norepinephrine efflux. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
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Details
- Title
- Local administration of a cannabinoid agonist alters norepinephrine efflux in the rat frontal cortex
- Creators
- M. E. Page - Jefferson Hospital for NeuroscienceV. C. Oropeza - Jefferson Hospital for NeuroscienceE. J. Van Bockstaele - Thomas Jefferson University
- Publication Details
- Neuroscience letters, v 431(1), pp 1-5
- Publisher
- Elsevier
- Number of pages
- 5
- Grant note
- R01DA009082 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission R01 DA020129; DA 09082; R01 DA009082-06S2; R01 DA020129-04S1; R01 DA009082; K02 DA015395-05; DA 15395; R01 DA020129-04; R01 DA009082-07; DA 020129; K02 DA015395 / NIDA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000253188100001
- Scopus ID
- 2-s2.0-38049026711
- Other Identifier
- 991021903411804721
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- Web of Science research areas
- Neurosciences