Journal article
Local and Global Behavior of Unfolded and Intrinsically Disordered Peptides and Proteins
Chembiochem : a European journal of chemical biology, v 26(15), e202500172
22 Aug 2025
PMID: 40614117
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Intrinsically disordered and artificially denatured foldable proteins have many properties in common, even though the distribution of amino acid residues generally differ. Both are traditionally described as either adopting molten globule or random coil-like structure, depending on their amino acid composition. For a long period of time, it was believed that with the exception of glycine and proline, conformational preferences of individual amino acid residues are very similar, and therefore, not of great concern. This article discusses experimental and bioinformatical data which show that individual Ramachandran plot distributions in unfolded proteins depend on the characteristics of side chains. Furthermore, ample experimental evidence suggests the presence of nearest neighbor interactions between residues which are ignored in the classical random coil model. The article reviews and discusses work that emphasizes the necessity of a thorough understanding of the local behavior of disordered and unfolded proteins alike for an understanding of the coiled state of proteins. Unresolved issues are delineated and research perspectives suggested.
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Details
- Title
- Local and Global Behavior of Unfolded and Intrinsically Disordered Peptides and Proteins
- Creators
- Reinhard Schweitzer-Stenner (Corresponding Author) - Drexel University
- Publication Details
- Chembiochem : a European journal of chemical biology, v 26(15), e202500172
- Publisher
- Wiley
- Number of pages
- 23
- Grant note
- MCB-1817650 / National Science Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:001522570600001
- Scopus ID
- 2-s2.0-105009865162
- Other Identifier
- 991022061654504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Chemistry, Medicinal